Evidence map›Paper›PMID 29446769›Full record

ReviewNature reviews. Disease primers2018

Vascular cognitive impairment.

Wiesje M van der Flier, Ingmar Skoog, Julie A Schneider, Leonardo Pantoni, Vincent Mok, Christopher L H Chen, Philip Scheltens

2 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Disease primers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 335 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
335citing papers in PubMed, 9 pooled it
31.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05565976 phase2 / phase3unknown statusstarted 2020, after this paper: background citation

Dapagliflozin Effect in Cognitive Impairment in Stroke Trial

Ran2020Enrolled270Registered outcomes3Posted comparisons0ConditionsDementia, Vascular, Metabolic Syndrome, Mild Cognitive Impairment, Stroke, IschemicArmsAntidiabetic, Dapagliflozin 10mg Tab, Platelet Antiaggregant, Statins (Cardiovascular Agents)
PMID 33282811PMID 20204386PMID 23040716PMID 28095900PMID 28950419PMID 29016744PMID 29371333PMID 29573529PMID 31236801PMID 31248555PMID 31535829PMID 32115470other papers from this trial
Open the trial in the graph
NCT07177781 narecruitingnot on this mapstarted 2024, after this paper: background citation

Longer-term Effects of Wild Blueberry Consumption on Brain Function in Older Men and Women

TypeinterventionalSponsorMaastricht University Medical CenterRan2024 to 2026Enrolled36ConditionsBrain Insulin-sensitivity, Brain Vascular Function, Cerebral Blood FlowArmsWild blueberry powder
3 · Its place in the literature

Who cites it

335 citing papers in PubMed, 9 syntheses or guidelines pooled it, 579 citations in OpenAlex.

  1. Pooled it
  2. Efficacy and safety ofFrontiers in pharmacology · 2026
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  14. Depression and anxiety in vascular dementia: an update.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
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275 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 6 countries.

Wiesje M van der FlierAlzheimer Center, Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, de Boelelaan 1118, 1081 HZ Amsterdam, Netherlands.
Ingmar SkoogCenter for Ageing and Health, Institute for Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Julie A SchneiderDepartments of Pathology and Neurological Sciences, Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Leonardo PantoniL. Sacco Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.
Vincent MokTherese Pei Fong Chow Research Center for Prevention of Dementia, Lui Che Woo Institute of Innovative Medicine, Gerald Choa Neuroscience Center, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong.
Christopher L H ChenDepartments of Pharmacology and Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Memory Aging and Cognition Centre, National University Health System, Singapore.
Philip ScheltensAlzheimer Center, Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, de Boelelaan 1118, 1081 HZ Amsterdam, Netherlands.
Amsterdam Neuroscience · NLChinese University of Hong Kong · CNNational University Health System · SGRush University Medical Center · USUniversity of Gothenburg · SEUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The term vascular cognitive impairment (VCI) was introduced around the start of the new millennium and refers to the contribution of vascular pathology to any severity of cognitive impairment, ranging from subjective cognitive decline and mild cognitive impairment to dementia. Although vascular pathology is common in elderly individuals with cognitive decline, pure vascular dementia (that is, dementia caused solely by vascular pathology) is uncommon. Indeed, most patients with vascular dementia also have other types of pathology, the most common of which is Alzheimer disease (specifically, the diffuse accumulation of amyloid-β plaques and neurofibrillary tangles composed of tau). At present, the main treatment for VCI is prevention by treating vascular diseases and other risk factors for VCI, such as hypertension and diabetes mellitus. Despite the current paucity of disease-modifying pharmacological treatments, we foresee that eventually, we might be able to target specific brain diseases to prevent cognitive decline and dementia.

Indexed as

BrainCognitive DysfunctionDementia, VascularHumansNeuroimagingRisk Factors

Identifiers

PMID29446769
OpenAlexW2794044390

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.