Evidence map›Paper›PMID 29446322›Full record

ArticleThe Journal of international medical research2018

BOLD MRI to evaluate early development of renal injury in a rat model of diabetes.

Qidong Wang, Chuangen Guo, Lan Zhang, Rui Zhang, Zhaoming Wang, Ying Xu, Wenbo Xiao

Open access · goldAbstract read
In one paragraph

Article in The Journal of international medical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Multiparametric MR Imaging for Evaluating Renal Function and Microstructure.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026
    Review
  2. Review
  3. Magnetic resonance imaging of renal oxygenation.Nature reviews. Nephrology · 2025
    Review
  4. BOLD MRI to Evaluate the Effects of Sacubitril/Valsartan on Renal Protection in Type 2 Diabetics.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Qidong Wang1 Department of Radiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Chuangen Guo1 Department of Radiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Lan Zhang2 Department of Radiology, The Fourth Affiliated Hospital, School of Medicine, Zhejiang University, Yiwu, China.
Rui Zhang1 Department of Radiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Zhaoming Wang3 Department of Pathology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Ying Xu4 Department of Nephrology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Wenbo Xiao1 Department of Radiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Zhejiang University · CNZero to Three · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective To investigate changes in renal oxygenation levels by blood-oxygenation-level dependent (BOLD)-magnetic resonance imaging (MRI), and to evaluate BOLD-MRI for detecting early diabetic renal injury. Methods Seventy-five rats, with unilateral nephrectomy, were randomly divided into streptozotocin-induced diabetes mellitus (DM, n = 65) and normal control (NC, n = 10) groups. BOLD-MRI scans were performed at baseline (both groups) and at 3, 7, 14, 21, 28, 35, 42, 49, 56, 63 and 70 days (DM only). Renal cortical (C) and medullary (M) R2* signals were measured and R2* medulla/cortex ratio (MCR) was calculated. Results DM-group CR2* and MR2* values were significantly higher than NC values following diabetes induction. R2* values increased gradually and peaked at day 35 (CR2*, 33.95 ± 0.34 s

Indexed as

Magnetic Resonance ImagingAlbuminuriaAnimalsDiabetes Mellitus, ExperimentalDisease Models, AnimalImage Processing, Computer-AssistedKidneyMaleOxygenRats, Sprague-DawleyStreptozocinOxygenStreptozocinBlood oxygen level dependentdiabeteskidneymagnetic resonance imagingrenal injury

Identifiers

PMID29446322
PMCPMC6091826
OpenAlexW2788582608

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.