ArticleJournal of biomedical optics2018
Pulsed terahertz imaging of breast cancer in freshly excised murine tumors.
Article in Journal of biomedical optics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Terahertz Imaging for Breast Cancer Detection in Animal Models: A Literature Review with Narrative Synthesis.Medical sciences (Basel, Switzerland) · 2026Pooled it
- Review
- Article
- Biomedical application of terahertz imaging technology: a narrative review.Quantitative imaging in medicine and surgery · 2023Review
- Review
- Terahertz imaging of human skin pathologies using laser feedback interferometry with quantum cascade lasers.Biomedical optics express · 2023Article
- Visual Enhancement and Semantic Segmentation of Murine Tissue Scans with Pulsed THz Spectroscopy.Proceedings. IEEE International Conference on Semantic Computing · 2023Article
- Advances in terahertz technology for cancer detection applications.Optical and quantum electronics · 2023Review
- Deep Learning Classification of Breast Cancer Tissue from Terahertz Imaging Through Wavelet Synchro-Squeezed Transformation and Transfer Learning.Journal of infrared, millimeter and terahertz waves · 2022Article
- Hyperspectral terahertz imaging and optical clearance for cancer classification in breast tumor surgical specimen.Journal of medical imaging (Bellingham, Wash.) · 2022Article
- Terahertz Imaging for Breast Cancer Detection.Sensors (Basel, Switzerland) · 2021Review
- Disassembly of microtubules by intense terahertz pulses.Biomedical optics express · 2021Article
- Mammary tumors in Sprague Dawley rats induced by N-ethyl-N-nitrosourea for evaluating terahertz imaging of breast cancer.Journal of medical imaging (Bellingham, Wash.) · 2021Article
- Article
- Terahertz Imaging and Characterization Protocol for Freshly Excised Breast Cancer Tumors.Journal of visualized experiments : JoVE · 2020Article
- Breast Cancer Detection with Low-dimension Ordered Orthogonal Projection in Terahertz Imaging.IEEE transactions on terahertz science and technology · 2020Article
- Automatic recognition of breast invasive ductal carcinoma based on terahertz spectroscopy with wavelet packet transform and machine learning.Biomedical optics express · 2020Article
- Terahertz Imaging and Spectroscopy in Cancer Diagnostics: A Technical Review.BME frontiers · 2020Review
- Terahertz tomographic imaging of freshly excised human breast tissues.Journal of medical imaging (Bellingham, Wash.) · 2019Article
- Cancer detection in excised breast tumors using terahertz imaging and spectroscopy.Biomedical spectroscopy and imaging · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
This paper investigates terahertz (THz) imaging and classification of freshly excised murine xenograft breast cancer tumors. These tumors are grown via injection of E0771 breast adenocarcinoma cells into the flank of mice maintained on high-fat diet. Within 1 h of excision, the tumor and adjacent tissues are imaged using a pulsed THz system in the reflection mode. The THz images are classified using a statistical Bayesian mixture model with unsupervised and supervised approaches. Correlation with digitized pathology images is conducted using classification images assigned by a modal class decision rule. The corresponding receiver operating characteristic curves are obtained based on the classification results. A total of 13 tumor samples obtained from 9 tumors are investigated. The results show good correlation of THz images with pathology results in all samples of cancer and fat tissues. For tumor samples of cancer, fat, and muscle tissues, THz images show reasonable correlation with pathology where the primary challenge lies in the overlapping dielectric properties of cancer and muscle tissues. The use of a supervised regression approach shows improvement in the classification images although not consistently in all tissue regions. Advancing THz imaging of breast tumors from mice and the development of accurate statistical models will ultimately progress the technique for the assessment of human breast tumor margins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.