Evidence map›Paper›PMID 29445961›Full record

ArticleInternational orthopaedics2018

Application of combined porous tantalum scaffolds loaded with bone morphogenetic protein 7 to repair of osteochondral defect in rabbits<sup/>.

Qian Wang, Hui Zhang, Hongquan Gan, Hui Wang, Qijia Li, Zhiqiang Wang

Abstract read
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In one paragraph

Article in International orthopaedics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 42 citations in OpenAlex.

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  6. Porous metal implants: processing, properties, and challenges.International journal of extreme manufacturing · 2023
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  7. The dietary supplement CyplexinolJournal of clinical and translational research · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Qian WangExperimental Center, North China University of Science and Technology, Tangshan, 063000, China.ORCID http://orcid.org/0000-0002-6470-2234
Hui ZhangDepartment of Joint Surgery 1, The Second Hospital of Tangshan, Tangshan, 063000, China.
Hongquan GanDepartment of Orthopaedics, Affiliated Hospital, North China University of Science and Technology, No. 73 Jianshe Road, Tangshan, 063000, China.
Hui WangHand Surgery Department, The Second Hospital of Tangshan, Tangshan, 063000, China.
Qijia LiExperimental Center, North China University of Science and Technology, Tangshan, 063000, China.
Zhiqiang WangDepartment of Orthopaedics, Affiliated Hospital, North China University of Science and Technology, No. 73 Jianshe Road, Tangshan, 063000, China. wzhqde@163.com.
North China University of Science and Technology · CNSecond Hospital of Tangshan · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePorous tantalum (PT) has been widely used in orthopaedic applications for low modulus of elasticity, excellent biocompatibility, and the microstructures similar to cancellous bone. In order to improve the biological activity of PT, biologically active factors can be combined with the material. The purpose of this study was to investigate if bone morphogenetic protein 7 (BMP-7) modifications could enhance the repairing of cartilage of PT in osteochondral defect in medial femoral condyle of rabbits.

methodsA cylindrical osteochondral defect model was created on the animal medial femoral condyle of and filled as follows: PT modified with BMP-7 for MPT group, non-modified PT for the PT group, while no implants were used for the blank group. The regenerated osteochondral tissue was assessed and analyzed by histological observations at four, eight and 16 weeks post-operation and evaluated in an independent and blinded manner by five different observers using a histological score. Osteochondral and subchondral bone defect repair was assessed by micro-CT scan at 16 weeks post-operation, while the biomechanical test was performed at 16 weeks post-operation.

resultsBriefly, higher overall histological score was observed in the MPT group compared to PT group. Furthermore, more new osteochondral tissue and bone formed at the interface and inside the inner pores of scaffolds of the MPT group compared to PT group. Additionally, the micro-CT data suggested that the new bone volume fractions and the quantity and quality of trabecular bone, as well as the maximum release force of the bone, were higher in the MPT group compared to PT group.

conclusionsWe demonstrated that the applied modified PT with BMP-7 promotes excellent subchondral bone regeneration and may serve as a novel approach for osteochondral defects repair.

Indexed as

AnimalsBone Morphogenetic Protein 7Bone RegenerationCartilage, ArticularDisease Models, AnimalFemurMaleRabbitsTantalumTissue EngineeringTissue ScaffoldsX-Ray MicrotomographyBMP7 protein, humanBone Morphogenetic Protein 7TantalumBone morphogenetic protein 7Cartilage engineeringOsteochondral defectsPorous tantalumScaffolds

Identifiers

PMID29445961
OpenAlexW2793578082

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.