Evidence map›Paper›PMID 29445911›Full record

ArticleHepatology international2018

High prevalence of HCV (GT4)-related TSH abnormality among 13402 Egyptian patients treated with direct acting antiviral therapy.

Rasha Eletreby, Mohamed Said, Zeinab Abdellatif, Yasmin Saad, Magdy ElSerafy, Hosam Dabes, Kadry ElSaeed, Yehia El-Shazly, Wahid Doss

Abstract read
PubMed Publisher
In one paragraph

Article in Hepatology international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Rasha EletrebyHepatology and Endemic Medicine Department, Cairo University, Cairo, 11311, Egypt. r_m_tawfik@yahoo.com.
Mohamed SaidHepatology and Endemic Medicine Department, Cairo University, Cairo, 11311, Egypt.
Zeinab AbdellatifHepatology and Endemic Medicine Department, Cairo University, Cairo, 11311, Egypt.
Yasmin SaadHepatology and Endemic Medicine Department, Cairo University, Cairo, 11311, Egypt.
Magdy ElSerafyHepatology and Endemic Medicine Department, Cairo University, Cairo, 11311, Egypt.
Hosam DabesMedical National Institute, Damnhour, Beheira, Egypt.
Kadry ElSaeedInternal Medicine Department, Ain Shams University, Cairo, Egypt.
Yehia El-ShazlyInternal Medicine Department, Ain Shams University, Cairo, Egypt.
Wahid DossHepatology and Endemic Medicine Department, Cairo University, Cairo, 11311, Egypt.
Cairo University · EGAin Shams University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHCV is associated with several extra hepatic diseases including thyroid dysfunction. This study aims at evaluating prevalence of thyroid dysfunction and its possible predictors in a large cohort of HCV GT4-infected patients, and the role of thyroid dysfunction as a predictor of response in the setting of direct acting antivirals (DAAs).

methodsPatients registered on the web-based registry system to receive therapy for chronic HCV in Beheira governorate viral hepatitis specialized treatment center affiliated to the National committee for control of viral hepatitis (NCCVH), Ministry of health, Egypt in the period from January 2015 to October 2016. Their data were exported and analyzed for the prevalence of thyroid dysfunction and its associated variables.

resultsOut of 13,402 patients, 2833 (21.1%) had elevated TSH level > 4.5 mIU/l (hypothyroidism). Female gender (62.7%), older age, higher FIB4, AST, and BMI and lower albumin were significantly associated with elevated TSH level on univariate analysis, while liver stiffness measured by fibroscan was not significantly associated. On the other hand, 466 patients (3.5%) showed low TSH level < 0.4 mIU/l (hyperthyroidism). Older age (median 52 years) and male gender (51.5%) were the only significantly associated variables. No association was found between SVR and baseline TSH level. Follow-up of 236 patients after SVR revealed improvement in TSH level in 80% of them.

conclusionHypothyroidism is prevalent in patients with chronic HCV GT4, and is influenced by patient gender and age. Pretreatment TSH does not affect SVR after DAAs. Despite limited data SVR achievement after DAAs improves thyroid dysfunction.

Indexed as

AdultAntiviral AgentsEgyptFemaleGenotypeHepatitis C, ChronicHumansHyperthyroidismHypothyroidismMaleMiddle AgedRetrospective StudiesThyrotropinTreatment OutcomeAntiviral AgentsThyrotropinGenotype IVHCVThyroid dysfunction

Identifiers

PMID29445911
OpenAlexW2792324512

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.