Evidence map›Paper›PMID 29445881›Full record

ArticleClinical oral investigations2018

Study of salivary and serum vaspin and total antioxidants in anorexia nervosa.

Elzbieta Paszynska, Marta Tyszkiewicz-Nwafor, Agnieszka Slopien, Monika Dmitrzak-Weglarz, Agata Dutkiewicz, Teresa Grzelak

Open access · hybridAbstract readControlled Clinical Trial
PubMed Publisher
In one paragraph

Article in Clinical oral investigations, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Elzbieta PaszynskaDepartment of Integrated Dentistry, Poznan University of Medical Sciences, Bukowska str 70, 60-812, Poznan, Poland. paszynska@ump.edu.pl.
Marta Tyszkiewicz-NwaforDepartment of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Szpitalna str 27/33, 60-572, Poznan, Poland.
Agnieszka SlopienDepartment of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Szpitalna str 27/33, 60-572, Poznan, Poland.
Monika Dmitrzak-WeglarzPsychiatric Genetics Unit, Department of Psychiatry, Poznan University of Medical Sciences, Rokietnicka str 8, 60-812, Poznan, Poland.
Agata DutkiewiczDepartment of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Szpitalna str 27/33, 60-572, Poznan, Poland.
Teresa GrzelakDivision of Biology of Civilization-Linked Diseases, Department of Chemistry and Clinical Biochemistry, Poznan University of Medical Sciences, Swiecickiego str 6, 60-781, Poznan, Poland.
Poznan University of Medical Sciences · PLHeliodor Swiecicki Clinical Hospital · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPatients with anorexia nervosa (AN) are primarily at high risk of multiple somatic complications, including oral diseases. In recent years, a number of new molecules that may play a potentially important role in AN progress and prognosis have been identified in saliva, but their exact roles are still poorly understood. Two such group of substances are antioxidants and vaspin. The purpose of this observational, cross-sectional study was to measure both the salivary and serum total antioxidant status (TAS), and vaspin (VASP) concentrations of patients with AN in comparison to an average population. MATERIAL AND

methodsNinety subjects participated (30 patients with AN, 60 matched healthy control subjects). A clinical examination was made, and blood and salivary samples were taken during the acute stage of AN (BMI < 15 kg/m

resultsAnorexic patients had significant reductions in salivary flow, TAS, and an elevation in VASP levels in their saliva and serum. Significant correlations between TAS, VASP, salivary flow, and nutritional status were detected.

conclusionDetermination of TAS and VASP in combined biological material confirmed that saliva might be a reliable non-invasive source of information for potent nutritional biomarkers. CLINICAL RELEVANCE: Our findings suggest that VASP cannot be excluded, as its increased concentration in saliva is an adaptive mechanism in reduced TAS, one resulting from diminished salivary secretion. It is therefore worth conducting further research aimed at recognizing the role of TAS and VASP in the saliva of underweight patients.

Indexed as

AdolescentAnorexia NervosaAntioxidantsBiomarkersCase-Control StudiesCross-Sectional StudiesEnzyme-Linked Immunosorbent AssayFemaleHumansMaleSalivaSerpinsAntioxidantsBiomarkersSERPINA12 protein, humanSerpinsAdaptive mechanismAnorexia nervosaAntioxidantsBiomarkersTransformationVaspin

Identifiers

PMID29445881
OpenAlexW2790229239

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.