Evidence map›Paper›PMID 29445755›Full record

ArticleJournal of immunology research2017

Immunomodulatory Effect of Flavonoids of Blueberry (

Dazhi Shi, Mengyi Xu, Mengyue Ren, Enshan Pan, Chaohua Luo, Wei Zhang, Qingfa Tang

Open access · goldAbstract read
In one paragraph

Article in Journal of immunology research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 25 citations in OpenAlex.

  1. Plants (Basel, Switzerland) · 2021
    Article
  2. Article
  3. Article
  4. Review
  5. Hypoglycemic activity and constituents analysis of blueberry (Diabetes, metabolic syndrome and obesity : targets and therapy · 2018
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Dazhi ShiSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
Mengyi XuSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
Mengyue RenSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.ORCID 0000-0002-1269-8931
Enshan PanSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
Chaohua LuoSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
Wei ZhangState Key Laboratory of Quality Research in Chinese Medicines, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau.ORCID 0000-0002-8340-0821
Qingfa TangSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.ORCID 0000-0001-9965-1150
Southern Medical University · CNMacau University of Science and Technology · MO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to explore the immunoregulatory effect of flavonoids of blueberry (

methodsThe flavonoids of blueberry leaves were prepared with 70% ethanol and were identified by ultraperformance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC/Q-Tof-MS). The immunoregulatory effect and possible regulatory mechanisms of FBL were investigated in lipopolysaccharide- (LPS-) induced RAW 264.7 cells.

resultsAccording to the results of UPLC/Q-Tof-MS, nine flavonoids of blueberry leaves were identified. FBL showed a significant reduction in the production of TNF-

conclusionOur study showed the immunoregulatory effect of FBL through the suppression of TNF-

Indexed as

AnimalsAnti-Inflammatory AgentsBlueberry PlantsEthanolFlavonoidsImmunosuppression TherapyInflammationLipopolysaccharidesMacrophagesMiceNF-kappa BNitric OxidePlant ExtractsPlant LeavesRAW 264.7 CellsSignal TransductionAnti-Inflammatory AgentsEthanolFlavonoidsLipopolysaccharidesNF-kappa BNitric OxidePlant ExtractsTumor Necrosis Factor-alpha

Identifiers

PMID29445755
PMCPMC5763064
OpenAlexW2775972192

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.