ArticleJournal of diabetes research2017
The Association between Monocyte Surface CD163 and Insulin Resistance in Patients with Type 2 Diabetes.
Article in Journal of diabetes research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04604041 (Investigation of Subclinical Markers of Multiple Sclerosis), which is not on this map. Cited by 15 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation of Subclinical Markers of Multiple Sclerosis
Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
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- Interleukin-10 attenuates renal injury after myocardial infarction in diabetes.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2022Article
- Nitazoxanide Exerts Immunomodulatory Effects on Peripheral Blood Mononuclear Cells from Type 2 Diabetes Patients.Biomolecules · 2021Article
- Single-cell RNA Seq reveals cellular landscape-specific characteristics and potential etiologies for adolescent idiopathic scoliosis.JOR spine · 2021Article
- An Analysis of the Multifaceted Roles of Heme in the Pathogenesis of Cancer and Related Diseases.Cancers · 2021Review
- Insulin resistance is linked to a specific profile of immune activation in human subjects.Scientific reports · 2021Article
- Deep Learning for Integrated Analysis of Insulin Resistance with Multi-Omics Data.Journal of personalized medicine · 2021Article
- Physiological and Immunological Causes of the Susceptibility of Chronic Inflammatory Patients to COVID-19 Infection: Focus on Diabetes.Frontiers in endocrinology · 2021Review
- IL-10 provides cardioprotection in diabetic myocardial infarction via upregulation of Heme clearance pathways.JCI insight · 2020Article
- Targeting of CD163International journal of molecular sciences · 2020Review
- Whole-blood transcriptome profiling reveals signatures of metformin and its therapeutic response.PloS one · 2020Article
- Salt-sensitive increase in macrophages in the kidneys of Dahl SS rats.American journal of physiology. Renal physiology · 2019Article
- Proteins Altered by Surgical Weight Loss Highlight Biomarkers of Insulin Resistance in the Community.Arteriosclerosis, thrombosis, and vascular biology · 2019Article
- Age-related M1/M2 phenotype changes in circulating monocytes from healthy/unhealthy individuals.Aging · 2018Article
- Role of Adaptive and Innate Immunity in Type 2 Diabetes Mellitus.Journal of diabetes research · 2018Review
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the association between monocyte CD163 and insulin resistance in patients with type 2 diabetes.
methodsOne hundred sixty-six patients with type 2 diabetes without inflammatory or chronic kidney disease were recruited. The monocyte CD163 levels were measured by flow cytometry and soluble CD163 (sCD163) by ELISA. Insulin resistance was evaluated by the index of the homeostasis model assessment (HOMA-R).
resultsThe median sCD163 and monocyte CD163 expression levels were 582.9 (472.4-720.0) ng/ml and 6061 (4486-7876) mean fluorescent intensity (MFI), respectively. In a simple regression analysis, monocyte CD163 was inversely correlated with log [HOMA-R] (
conclusionsMonocyte surface CD163 expression levels were more significantly associated with insulin resistance than sCD163 in patients with type 2 diabetes, suggesting a novel pathophysiological role of CD163.
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Registered trials
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