ArticleJournal of biomedical physics & engineering2017
In-vitro Study of Photothermal Anticancer Activity of Carboxylated Multiwalled Carbon Nanotubes.
Article in Journal of biomedical physics & engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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Who cites it
1 citing paper in PubMed.
- Biophysical stimuli for promoting bone repair and regeneration.Medical review (2021) · 2025Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveMulti-walled Carbon Nano Tubes (MWCNTs) as an important element of nanosciences have a remarkable absorption in the region of NIR window (650-900 nm) which can overcome the limitations of deep treatment in photothermal therapy. To disperse MWCNTs in water, it is proposed to attach carboxylated functional group (-COOH) to MWCNTs in order to increase dispersivity in water. MATERIALS AND
methodsA stable suspension of MWCNTs-COOH with different concentrations (from 2.5 to 500 μg/ml) was prepared. Then, they were compared for their ability to increase temperature in the presence of 810 nm laser irradiation and through a wide range of radiation time (from 20 to 600 s) and three laser powers (1.5, 2 and 2.5 w). The temperature rise was recorded real time every 20 seconds by a precise thermometer.
resultsAbsorption spectrum of MWCNTs-COOH suspension was remarkably higher than water in a wavelength range of 200 to 1100 nm. For example, using the concentrations of 2.5 and 80 μg/ml of MWCNTs-COOH suspension caused a temperature elevation 2.35 and 9.23 times compared to water, respectively, upon 10 min laser irradiation and 2.5 w. Moreover, this predominance can be observed for 1.5 and 2 w radiation powers, too. Our findings show that the maximum of temperature increase was obtained at 80 μg/ml concentration of MWCNT-COOH suspension for three powers and through all periods of exposure time. Our results show that the minimum required parameters for a 5°C temperature increase (a 5°C temperature increase causes cell death) were achieved through 2.5 w, 28 μg/ml concentration and 20 second irradiation time in which both concentration and radiation times were relatively low.
conclusionOur results showed that MWCNTs-COOH can be considered as a potent photothermal agent in targeted therapies. New strategies must be developed to minimize the concentration, irradiation time and radiation power used in experiments.
Indexed as
Identifiers
29445711PMC5809927What OpenQuestion holds
Registered trials
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