Evidence map›Paper›PMID 29445430›Full record

ArticleJournal of vascular and interventional neurology2017

Seizure Prophylaxis in the Immediate Post-Hemorrhagic Period in Patients with Aneurysmal Subarachnoid Hemorrhage.

Thomas V Kodankandath, Salman Farooq, Wled Wazni, John-Andrew Cox, Christopher Southwood, Gregory Rozansky, Vijay Johnson, John R Lynch

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of vascular and interventional neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 3 pooled it
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Using artificial intelligence to optimize anti-seizure treatment and EEG-guided decisions in severe brain injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Thomas V KodankandathDepartment of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA.
Salman FarooqDepartment of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA.
Wled WazniDepartment of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA.
John-Andrew CoxDepartment of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA.
Christopher SouthwoodDepartment of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA.
Gregory RozanskyDepartment of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA.
Vijay JohnsonDepartment of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA.
John R LynchDepartment of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA.
Medical College of Wisconsin · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSeizures are a well-known complication of aneurysmal subarachnoid hemorrhage (aSAH) and occur most commonly in the immediate posthemorrhagic period. Most commonly used antiepileptic drugs (AEDs) for seizure prophylaxis in aSAH include phenytoin and levetiracetam. There is no reliable data available on the safety and efficacy of restricting AED prophylaxis only till the aneurysm is secured.

methodsWe retrospectively chart reviewed patients admitted to our neurosciences intensive care unit (NICU) with aSAH during the past two years. Seizure incidence was studied in patients treated with phenytoin versus levetiracetam and in patients treated for 3-7 days vs. those where AED was discontinued immediately after aneurysm was secured.

resultsIn 28 patients, AED prophylaxis was discontinued immediately after the aneurysm was secured, and in 21 patients, it was continued for 3-7 days. Of the 28 patients who received AED prophylaxis for less than or equal to two days, phenytoin was used in 20 patients and levetiracetam was used in eight patients. In patients receiving AED prophylaxis for 3-7 days, phenytoin was used in eight cases and levetiracetam was used in 13 cases. None of these patients had seizures reported during hospitalization or at three-month follow-up.

conclusionStopping the AED prophylaxis immediately after aneurysm coiling is not associated with increased risk of seizures. Seizures at presentation in patients with aSAH are not associated with development of epilepsy at three months. Both phenytoin and levetiracetam are well tolerated in patients with aSAH when limited to the immediate posthemorrhagic period.

Indexed as

aneurysmal subarachnoid hemorrhageantiepileptic drugslevetiracetamphenytoinseizures

Identifiers

PMID29445430
PMCPMC5805895
OpenAlexW2921022903

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.