Evidence map›Paper›PMID 29445414›Full record

ArticleImmunity & ageing : I & A2018

Effects of a new nutraceutical combination on cognitive function in hypertensive patients.

Giuseppe Giugliano, Alessia Salemme, Sara De Longis, Marialuisa Perrotta, Valentina D'Angelosante, Alessandro Landolfi, Raffaele Izzo, Valentina Trimarco

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity & ageing : I & A, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04705220 (Effect of Nutritional Supplementation With Turmeric on the Cognitive Performance of Subjects With Metabolic Syndrome), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04705220 nacompletednot on this mapstarted 2022, after this paper: background citation

Effect of Nutritional Supplementation With Turmeric on the Cognitive Performance of Subjects With Metabolic Syndrome

TypeinterventionalSponsorIndena S.p.ARan2022 to 2025Enrolled85ConditionsMild Cognitive ImpairmentArmsMERIVA® Tablets, Placebo Tablets
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Giuseppe Giugliano1Hypertension Research Center; Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy.
Alessia Salemme2Federico II University, Naples, Italy.
Sara De Longis3Hypertension Research Center; Department of Translational Medical Sciences, Federico II University, via Pansini 5, 80131 Naples, Italy.
Marialuisa Perrotta4Department of Angiocardioneurology and Translational Medicine, IRCCS Neuromed, Pozzilli, Isernia Italy.
Valentina D'Angelosante4Department of Angiocardioneurology and Translational Medicine, IRCCS Neuromed, Pozzilli, Isernia Italy.
Alessandro Landolfi4Department of Angiocardioneurology and Translational Medicine, IRCCS Neuromed, Pozzilli, Isernia Italy.
Raffaele Izzo3Hypertension Research Center; Department of Translational Medical Sciences, Federico II University, via Pansini 5, 80131 Naples, Italy.ORCID 0000-0002-0308-2836
Valentina Trimarco5Hypertension Research Center; Department of Neurosciences, Federico II University, Naples, Italy.
Federico II University Hospital · ITIstituto Neurologico Mediterraneo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic increased arterial blood pressure has been associated with executive dysfunction, slowing of attention and mental processing speed, and later with memory deficits. Due to the absence of a concrete therapeutic approach to this pathophysiological process, in the last decades there has been an increasing interest in the use of nutraceuticals, especially those with antioxidant properties, which own strong neuroprotective potential, that may help to improve cognitive function and to delay the onset of dementia.

resultsWe evaluated the effects of the treatment with a new nutraceutical preparation containing different molecules with potent antioxidant properties (AkP05, IzzeK®) and placebo on a cohort of thirty-six hypertensive patients. At baseline, neuropsychological evaluation, arterial stiffness and biochemical parameters of the subjects were comparable. After 6 months of treatment, there was a significant reduction of the augmentation index in the AkP05-treated group. Moreover, the measurement of cognitive function, evaluated with MoCA test and Word Match Testing, showed a significant improvement in patients receiving the active treatment. In addition, the group treated with nutraceutical reached a better Stroop test score, while subjects that received placebo did not showed any improvement. Finally, a positive relationship between SBP variation and the psychometric assessment with the EQ-VAS scale was observed only in the active treatment group.

conclusionsIn this study, we demonstrated that the therapy with a new nutraceutical preparation is able to significantly increase the scores of important neuropsychological tests in hypertensive patients already on satisfactory blood pressure control. Although future studies are needed to better characterize the molecular mechanisms involved, these results candidate the new nutraceutical combination as a possible therapeutic strategy to support the cerebrovascular functions and delay the onset of dementia in hypertensive patients.

Indexed as

Arterial stiffnessNeuropsychological evaluationNutraceutical

Identifiers

PMID29445414
PMCPMC5803913
OpenAlexW2800198594

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.