Evidence map›Paper›PMID 29445285›Full record

ReviewNeuropsychiatric disease and treatment2018

The effect of exercise on cancer-related fatigue in cancer survivors: a systematic review and meta-analysis.

Ellen Kessels, Olga Husson, Christina M van der Feltz-Cornelis

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Neuropsychiatric disease and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06624930 (A Randomized Controlled Trial Adding Behavioural Counselling to Supervised Physical Activity in Cancer Survivors), which is not on this map. Cited by 105 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 11 pooled it
8.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06624930 narecruitingnot on this mapstarted 2024, after this paper: background citation

A Randomized Controlled Trial Adding Behavioural Counselling to Supervised Physical Activity in Cancer Survivors

TypeinterventionalSponsorUniversity of TorontoRan2024 to 2029Enrolled236ConditionsCancer, ExerciseArmsBehavioural Counselling, Exercise Counselling
3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 11 syntheses or guidelines pooled it, 209 citations in OpenAlex.

  1. The effects of aerobic and resistance training across eight cancer types: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
  2. Patient attitudes and experiences towards exercise during oncological treatment. A qualitative systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  3. Management of Fatigue in Adult Survivors of Cancer: ASCO-Society for Integrative Oncology Guideline Update.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Guideline
  4. Pooled it
  5. Pooled it
  6. Effectiveness of exercise interventions in the management of cancer-related fatigue: a systematic review of systematic reviews.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
  7. Pooled it
  8. Systematic Review for the Medical Applications of Meditation in Randomized Controlled Trials.International journal of environmental research and public health · 2022
    Pooled it
  9. Pooled it
  10. Community-based exercise programs and cancer-related fatigue: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Pooled it
  11. Pooled it
  12. CanRestoreFunction: Cancer-related fatigue management eHealth intervention- a pilot pragmatic randomized-control trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Trial
  13. Trial
  14. The effects of early rehabilitation on physical and psychosocial functions after breast cancer surgery.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Trial
  15. Factors associated with significant improvement in cancer-related fatigue after completing cognitive behavioral therapy for insomnia in cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Trial
  16. Trial
  17. Trial
  18. Exploring the effect of exercise training on breast cancer's pathologic response and tumor immune microenvironment after neoadjuvant chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Trial
  19. The combined effect of physical exercise, pranayama, and diet on fatigue in adult cancer patients undergoing chemotherapy: a randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Trial
  20. Trial

45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Ellen KesselsTilburg University School of Social Sciences, Tranzo Academic Collaborative Centre "Geestdrift", Tilburg University.
Olga HussonThe Institute of Cancer Research, London, UK.
Christina M van der Feltz-CornelisTilburg University School of Social Sciences, Tranzo Academic Collaborative Centre "Geestdrift", Tilburg University.
Tilburg University · NLInstitute of Cancer Research · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe objective of the study was to conduct systematic review and meta-analysis to establish the effect of exercise interventions on cancer-related fatigue (CRF) in cancer survivors, compared to non-exercise intervention controls.

methodsTrials published between January 1st 2000 and August 17th 2016 were included through PubMed database search and search of references. Eligible trials compared the effect of an exercise intervention on CRF compared to non-exercise intervention controls, with CRF as primary outcome and measured by validated self-report questionnaire, in cancer survivors not receiving palliative care. We evaluated risk of bias of individual trials following Cochrane Quality criteria. We performed a random-effects meta-analysis in the low risk of bias trials with intervention type, exercise intensity, adherence, and cancer type as moderators, and also performed meta-regression analyses and a sensitivity analysis including the high risk of bias trials.

resultsOut of 274 trials, 11 met the inclusion criteria, of which six had low risk of bias. Exercise improved CRF with large effect size (Cohen's

conclusionExercise has a large effect on CRF in cancer survivors. Aerobic interventions with high adherence have the best result.

Indexed as

cancer-related fatiguecancer survivorsexercisemeta analysisrandomized clinical trialssystematic review

Identifiers

PMID29445285
PMCPMC5810532
OpenAlexW2787023313

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.