ArticleNeuropsychiatric disease and treatment2018
Application value of selected serum indicators in the differential diagnosis of geriatric depression and transient depressive state.
Article in Neuropsychiatric disease and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
- Article
- Association of Cortisol Levels With Neuropsychiatric Functions: A Mendelian Randomization Analysis.Frontiers in endocrinology · 2019Article
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6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundTransient depressive state (TDS) is a transient, negative emotional state caused by certain events or situations. Because of the similarity in depressive symptoms between depression and TDS that arise within 2 weeks of their onset, it is difficult to distinguish TDS from depression. The aims of the present study were to investigate the application value of selected serum indicators in the differential diagnosis of geriatric depression and TDS in the early stage and to provide evidence for treatment. PATIENTS AND
methodsIn this study, a total of 274 elderly patients were divided into the depression group (n=144) and the TDS group (n=130). All participants' serum samples were collected, and 9 selected serum indicators were analyzed. Afterward, 90 patients with depression and 90 patients with TDS were used to build the diagnostic model. A binary logistic regression analysis was used to establish regression models, and the area under the receiver operating characteristic (ROC) curve was drawn. Finally, another 54 patients with depression and 40 patients with TDS were used to validate our model.
resultsFor the 9 screening serum indicators, the 3 serum indicators selected to build the regression model were BDNF (
conclusionThe logistic regression model and ROC curves based on serum levels of BDNF, IL-1β, and cortisol could distinguish depression from TDS in early stage, which could provide assistance to the differential diagnosis of geriatric depression and TDS.
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