SynthesisInternational journal of chronic obstructive pulmonary disease2018
CT densitometry in emphysema: a systematic review of its clinical utility.
Synthesis in International journal of chronic obstructive pulmonary disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Pulmonary Function Decline in Alpha-1 Antitrypsin Deficiency: A Systematic Review and Meta-Analysis.International journal of chronic obstructive pulmonary disease · 2026Pooled it
- Phenotyping preserved ratio impaired spirometry (PRISm) using quantitative high-resolution computed tomography imaging features.Quantitative imaging in medicine and surgery · 2026Article
- Postoperative changes in low attenuation volume according to the number of resected subsegments: a retrospective cohort study.Journal of thoracic disease · 2026Article
- Lung densitometry in postmortem computed tomography - comparison across different fatal asphyxia groups.Forensic science, medicine, and pathology · 2025Article
- Proposal and Validation of the Minimum Clinically Important Difference in Emphysema Progression.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2025Article
- Densitometric and Functional Progression in Patients with Alpha-1 Antitrypsin Deficiency Genotype SZ.Journal of clinical medicine · 2025Article
- Assessing the efficacy of AlphaHeliyon · 2024Review
- Evaluation of retrieval accuracy and visual similarity in content-based image retrieval of chest CT for obstructive lung disease.Scientific reports · 2024Article
- Quality of Life and Mortality Outcomes for Augmentation Naïve and Augmented Patients with Severe Alpha-1 Antitrypsin Deficiency.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2023Article
- Emphysema Progression at CT by Deep Learning Predicts Functional Impairment and Mortality: Results from the COPDGene Study.Radiology · 2022Observational
- Diagnostic efficacy of visual subtypes and low attenuation area based on HRCT in the diagnosis of COPD.BMC pulmonary medicine · 2022Article
- Quantitative measurements of emphysema in ultra-high resolution computed tomography using model-based iterative reconstruction in comparison to that using hybrid iterative reconstruction.Physical and engineering sciences in medicine · 2022Article
- Chest CT scan for the screening of air anomalies at risk of pulmonary barotrauma for the initial medical assessment of fitness to dive in a military population.Frontiers in physiology · 2022Article
- Quantitative CT parameters correlate with lung function in chronic obstructive pulmonary disease: A systematic review and meta-analysis.Frontiers in surgery · 2022Review
- Validation of Noninvasive Remote Dielectric Sensing System to Quantify Lung Fluid Levels.Journal of clinical medicine · 2021Article
- FOOTPRINTS study protocol: rationale and methodology of a 3-year longitudinal observational study to phenotype patients with COPD.BMJ open · 2021Article
- Radiomics and Computerized Analysis of CT Images: Looking Forward.Radiology. Cardiothoracic imaging · 2020Article
- Correlation of positron emission tomography ventilation-perfusion matching with CT densitometry in severe emphysema.EJNMMI research · 2020Article
- Alpha-1 antitrypsin deficiency: an update on clinical aspects of diagnosis and management.Faculty reviews · 2020Review
- Protocol for the EARCO Registry: a pan-European observational study in patients with αERJ open research · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The aim of the study was to assess the relationship between computed tomography (CT) densitometry and routine clinical markers in patients with chronic obstructive pulmonary disease (COPD) and alpha-1 anti-trypsin deficiency (AATD). Methods: Multiple databases were searched using a combination of pertinent terms and those articles relating quantitatively measured CT densitometry to clinical outcomes. Studies that used visual scoring only were excluded, as were those measured in expiration only. A thorough review of abstracts and full manuscripts was conducted by 2 reviewers; data extraction and assessment of bias was conducted by 1 reviewer and the 4 reviewers independently assessed for quality. Pooled correlation coefficients were calculated, and heterogeneity was explored. Results: A total of 112 studies were identified, 82 being suitable for meta-analysis. The most commonly used density threshold was -950 HU, and a significant association between CT density and all included clinical parameters was demonstrated. There was marked heterogeneity between studies secondary to large variety of disease severity within commonly included cohorts and differences in CT acquisition parameters. Conclusion: CT density shows a good relationship to clinically relevant parameters; however, study heterogeneity and lack of longitudinal data mean that it is difficult to compare studies or derive a minimal clinically important difference. We recommend that international consensus is reached to standardize CT conduct and analysis in future COPD and AATD studies.
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