Evidence map›Paper›PMID 29445135›Full record

ArticleMucosal immunology2018

Alteration in nerves and neurotransmitter stimulation of lacrimal gland secretion in the TSP-1

Sumit Bhattacharya, Laura García-Posadas, Robin R Hodges, Helen P Makarenkova, Sharmila Masli, Darlene A Dartt

Open access · bronzeAbstract read
In one paragraph

Article in Mucosal immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Obstructive Sleep Apnea Affects Lacrimal Gland Function.Investigative ophthalmology & visual science · 2022
    Article
  6. Mouse Models of Sjögren's Syndrome with Ocular Surface Disease.International journal of molecular sciences · 2020
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Sumit BhattacharyaSchepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Laura García-PosadasSchepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Robin R HodgesSchepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Helen P MakarenkovaMolecular Medicine Department, The Scripps Research Institute, La Jolla, CA, USA.
Sharmila MasliDepartment of Ophthalmology, Boston University School of Medicine, Boston, MA, USA.
Darlene A DarttSchepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. darlene_dartt@meei.harvard.edu.
Massachusetts Eye and Ear Infirmary · USBoston University · USScripps Research Institute · US

Funding

VISION RESEARCHP30EY003790 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI Patricia Ann D'Amore · 1985 to 2026
$25.5M
MECHANISM OF LACRIMAL GLAND SECRETIONR01EY006177 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI DARTT, DARLENE A · 1985 to 2012
$5.7M
Lacrimal Gland Repair Using Progenitor CellsR01EY026202 · NEI · SCRIPPS RESEARCH INSTITUTE, THE · PI MAKARENKOVA, HELEN P. · 2016 to 2025
$5.2M
NEI NIH HHS P30 EY003790NEI NIH HHS R01 EY006177NEI NIH HHS R01 EY026202
6 · The paper itself

Abstract

The purpose of this study is to determine neural, vascular, protein secretion, and cellular signaling changes with disease progression in lacrimal glands of the thrombospondin-1

Indexed as

AnimalsCalcium Channels, L-TypeCalcium SignalingCells, CulturedDisease Models, AnimalDry Eye SyndromesFemaleHumansLacrimal ApparatusLeukocytes, MononuclearMiceMice, Inbred C57BLMice, KnockoutNeurotransmitter AgentsPeripheral NervesPotassium ChlorideCacna1d protein, mouseCalcium Channels, L-TypeNeurotransmitter AgentsPotassium ChlorideThbs1 protein, mouseThrombospondin 1

Identifiers

PMID29445135
PMCPMC6030454
OpenAlexW2791888015

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.