Evidence map›Paper›PMID 29445110›Full record

ArticleScientific reports2018

Promising Biomarkers of Environmental Enteric Dysfunction: A Prospective Cohort study in Pakistani Children.

Najeeha Talat Iqbal, Kamran Sadiq, Sana Syed, Tauseefullah Akhund, Fayyaz Umrani, Sheraz Ahmed, Mohammad Yawar Yakoob, Najeeb Rahman, Shahida Qureshi, Wenjun Xin and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 62 citations in OpenAlex.

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  3. Effect of one prophylactic dose of azithromycin on Bifidobacterium infantis colonization in infants from the Mumta trial.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Najeeha Talat IqbalDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Kamran SadiqDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Sana SyedDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Tauseefullah AkhundDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Fayyaz UmraniDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Sheraz AhmedDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Mohammad Yawar YakoobDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Najeeb RahmanDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Shahida QureshiDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Wenjun XinDepartment of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
Jennie Z MaDepartment of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
Molly HughesDepartment of Medicine, University of Virginia, Charlottesville, VA, USA.
Syed Asad AliDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan. asad.ali@aku.edu.
Aga Khan University · PKUniversity of Virginia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Environmental Enteric Dysfunction (EED), a syndrome characterized by chronic gut inflammation, contributes towards stunting and poor response to enteric vaccines in children in developing countries. In this study, we evaluated major putative biomarkers of EED using growth faltering as its clinical proxy. Newborns (n = 380) were enrolled and followed till 18 months with monthly anthropometry. Biomarkers associated with gut and systemic inflammation were assessed at 6 and 9 months. Linear mixed effects model was used to determine the associations of these biomarkers with growth faltering between birth and 18 months. Fecal myeloperoxidase (neutrophil activation marker) at 6 months [β = -0.207, p = 0.005], and serum GLP 2 (enterocyte proliferation marker) at 6 and 9 months [6M: β = -0.271, p = 0.035; 9M: β = -0.267, p = 0.045] were associated with decreasing LAZ score. Ferritin at 6 and 9 months was associated with decreasing LAZ score [6M: β = -0.882, p < 0.0001; 9M: β = -0.714, p < 0.0001] and so was CRP [β = -0.451, p = 0.039] and AGP [β = -0.443, p = 0.012] at 9 months. Both gut specific and systemic biomarkers correlated negatively with IGF-1, but only weakly correlated, if at all with each other. We therefore conclude that EED may be contributing directly towards growth faltering, and this pathway is not entirely through the pathway of systemic inflammation.

Indexed as

Models, StatisticalBiomarkersCohort StudiesEnterocytesEnvironmental ExposureFemaleGlucagon-Like Peptide 2HumansInfantInfant, NewbornInsulin-Like Growth Factor IIntestinal DiseasesMaleNeutrophil ActivationPakistanPeroxidaseBiomarkersGlucagon-Like Peptide 2IGF1 protein, humanInsulin-Like Growth Factor IPeroxidase

Identifiers

PMID29445110
PMCPMC5813024
OpenAlexW2800727394

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.