Evidence map›Paper›PMID 29445061›Full record

ArticleInternal medicine (Tokyo, Japan)2018

The Prophylactic Effect of Anti-influenza Agents for an Influenza Outbreak in a University Hospital.

Mao Hagihara, Yukiko Kato, Ai Kurumiya, Tomoko Takahashi, Miki Sakata, Hideo Kato, Daisuke Sakanashi, Atsuko Yamada, Hiroyuki Suematsu, Jun Hirai and 4 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Update on Influenza.The American journal of the medical sciences · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Mao HagiharaDepartment of Infection Control and Prevention, Aichi Medical University Hospital, Japan.
Yukiko KatoDepartment of Infection Control and Prevention, Aichi Medical University Hospital, Japan.
Ai KurumiyaDepartment of Infection Control and Prevention, Aichi Medical University Hospital, Japan.
Tomoko TakahashiDepartment of Infection Control and Prevention, Aichi Medical University Hospital, Japan.
Miki SakataDepartment of Infection Control and Prevention, Aichi Medical University Hospital, Japan.
Hideo KatoDepartment of Infection Control and Prevention, Aichi Medical University Hospital, Japan.
Daisuke SakanashiDepartment of Infection Control and Prevention, Aichi Medical University Hospital, Japan.
Atsuko YamadaDepartment of Infection Control and Prevention, Aichi Medical University Hospital, Japan.
Hiroyuki SuematsuDepartment of Infection Control and Prevention, Aichi Medical University Hospital, Japan.
Jun HiraiDepartment of Infection Control and Prevention, Aichi Medical University Hospital, Japan.
Naoya NishiyamaDepartment of Infection Control and Prevention, Aichi Medical University Hospital, Japan.
Yusuke KoizumiDepartment of Infection Control and Prevention, Aichi Medical University Hospital, Japan.
Yuka YamagishiDepartment of Infection Control and Prevention, Aichi Medical University Hospital, Japan.
Hiroshige MikamoDepartment of Infection Control and Prevention, Aichi Medical University Hospital, Japan.
Aichi Medical University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective From November 24 to December 9, 2013, an outbreak of the influenza (flu) A (H3) virus occurred in a tertiary-care university hospital (1,014 beds). We herein report the prophylactic effect of anti-flu agents for controlling the flu outbreak. Methods We administered pre- or post-exposure prophylaxis with anti-flu agents in flu outbreak. To test the effectiveness of prophylaxis in a flu outbreak, we used the posterior mean of the reproductive value during the pre- and post-intervention period. We also simulated the probability distribution of new flu cases. We performed an analysis to quantify the strength of the intervention effect. Results A total of 97 people were diagnosed with flu before the intervention, and 7 were diagnosed after the intervention. A molecular analysis of the flu virus revealed that this outbreak was due to the flu A (H3) virus. A total of 3,702 people received prophylaxis. There was a significant reduction in the reproductive value from 1.89 [95% confidence interval (CI), 1.59 to 2.24] to 0.65 (95% CI, 0.02 to 1.00) after the intervention (p<0.001). Conclusion Prophylaxis with anti-flu agents, along with prompt identification and isolation of infected individuals, was effective in reducing the impact of a flu outbreak in a hospital.

Indexed as

Antiviral AgentsDisease OutbreaksFemaleHospitals, UniversityHumansInfluenza, HumanMaleOseltamivirAntiviral AgentsOseltamivirinfluenza (flu)oseltamiviroutbreakprophylaxiszanamivir

Identifiers

PMID29445061
PMCPMC5849543
OpenAlexW2785410212

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.