Evidence map›Paper›PMID 29444897›Full record

ArticleEMBO molecular medicine2018

Role of NKp46

Eline Haspeslagh, Mary J van Helden, Kim Deswarte, Sofie De Prijck, Justine van Moorleghem, Louis Boon, Hamida Hammad, Eric Vivier, Bart N Lambrecht

Open access · goldAbstract read
In one paragraph

Article in EMBO molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Natural killer cells in the lung: potential role in asthma and virus-induced exacerbation?European respiratory review : an official journal of the European Respiratory Society · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Innate-like Lymphocytes and Innate Lymphoid Cells in Asthma.Clinical reviews in allergy & immunology · 2020
    Review
  13. Article
  14. Article
  15. Contributions of innate lymphocytes to allergic responses.Current opinion in allergy and clinical immunology · 2019
    Review
  16. Natural Killer Cells in the Lungs.Frontiers in immunology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Eline HaspeslaghImmunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium.
Mary J van HeldenImmunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium.
Kim DeswarteImmunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium.
Sofie De PrijckImmunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium.
Justine van MoorleghemImmunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium.
Louis BoonBioceros BV, Utrecht, The Netherlands.
Hamida HammadImmunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium.
Eric VivierCentre d'Immunologie de Marseille-Luminy, Inserm, CNRS, Aix Marseille Université Parc Scientifique & Technologique de Luminy, Marseille Cedex, France.
Bart N LambrechtImmunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium bart.lambrecht@ugent.be.ORCID 0000-0003-4376-6834
Ghent University · BECentre National de la Recherche Scientifique · FRErasmus MC · NLPolpharma Biologics (Netherlands) · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

House dust mite (HDM)-allergic asthma is driven by T helper 2 (Th2) lymphocytes, but also innate immune cells control key aspects of the disease. The precise function of innate natural killer (NK) cells during the initiation and propagation of asthma has been very confusing, in part because different, not entirely specific, strategies were used to target these cells. We show that HDM inhalation rapidly led to the accumulation of NK cells in the lung-draining lymph nodes and of activated CD69

Indexed as

AnimalsAntigens, LyAsthmaFemaleKiller Cells, NaturalMaleMiceMice, Inbred C57BLNatural Cytotoxicity Triggering Receptor 1NK Cell Lectin-Like Receptor Subfamily KPyroglyphidaeAntigens, LyKlrk1 protein, mouseNatural Cytotoxicity Triggering Receptor 1Ncr1 protein, mouseNK Cell Lectin-Like Receptor Subfamily Kallergic asthmahouse dust miteNK cellsNKG2DNKp46

Identifiers

PMID29444897
PMCPMC5887908
OpenAlexW2788372790

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.