Evidence map›Paper›PMID 29444862›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Targeted DNA demethylation of the

Javier Gallego-Bartolomé, Jason Gardiner, Wanlu Liu, Ashot Papikian, Basudev Ghoshal, Hsuan Yu Kuo, Jenny Miao-Chi Zhao, David J Segal, Steven E Jacobsen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers.

0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed
41.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

140 citing papers in PubMed, 277 citations in OpenAlex.

  1. Review
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  3. Review
  4. Article
  5. Epigenome Editing for Cannabinoid Yield: Targets, Tools, and Priorities inInternational journal of molecular sciences · 2026
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. A Modular and Customizable CRISPR/Cas Toolkit for Epigenome Editing of Cis-regulatory Modules.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  17. Review
  18. Article
  19. Review
  20. Review

80 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Javier Gallego-BartoloméDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095.
Jason GardinerDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095.
Wanlu LiuDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095.
Ashot PapikianDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095.
Basudev GhoshalDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095.
Hsuan Yu KuoDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095.
Jenny Miao-Chi ZhaoDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095.
David J SegalGenome Center, Medical Investigation of Neurodevelopmental Disorders Institute, and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA 95616.ORCID 0000-0001-8962-3105
Steven E JacobsenDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095; jacobsen@ucla.edu.
University of California, Los Angeles · USHoward Hughes Medical Institute · USUniversity of California, Davis · US

Funding

CRISPR-based epigenetic modifiersR21CA204563 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SEGAL, DAVID J · 2016 to 2017
$732k
Howard Hughes Medical InstituteNCI NIH HHS R21 CA204563
6 · The paper itself

Abstract

DNA methylation is an important epigenetic modification involved in gene regulation and transposable element silencing. Changes in DNA methylation can be heritable and, thus, can lead to the formation of stable epialleles. A well-characterized example of a stable epiallele in plants is

Indexed as

DNA MethylationGenome, PlantArabidopsisArabidopsis ProteinsCatalytic DomainDNA, PlantDNA Transposable ElementsEpigenesis, GeneticFlowersGene Expression Regulation, PlantGene SilencingHomeodomain ProteinsHumansMixed Function OxygenasesMutationPromoter Regions, GeneticArabidopsis ProteinsDNA, PlantDNA Transposable ElementsHomeodomain ProteinsMixed Function OxygenasesProto-Oncogene ProteinsTET1 protein, humanTranscription FactorsArabidopsisartificial zinc fingerCRISPR/dCas9 SunTagtargeted demethylationTET1

Identifiers

PMID29444862
PMCPMC5834696
OpenAlexW2790839956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.