Evidence map›Paper›PMID 29444855›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Role of glutathione metabolism in host defense against

Mariska Kerstholt, Hedwig Vrijmoeth, Ekta Lachmandas, Marije Oosting, Mihaela Lupse, Mirela Flonta, Charles A Dinarello, Mihai G Netea, Leo A B Joosten

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
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  3. Review
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  5. Review
  6. Review
  7. Modulation of Macrophage Redox and Apoptotic Processes toPathogens (Basel, Switzerland) · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Redox Imbalance and Its Metabolic Consequences in Tick-Borne Diseases.Frontiers in cellular and infection microbiology · 2022
    Review
  14. Article
  15. Metabolic Response in Patients With Post-treatment Lyme Disease Symptoms/Syndrome.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  16. Article
  17. Article
  18. Article
  19. Comprehensive Mapping of the Cell Response toFrontiers in microbiology · 2021
    Article
  20. Effect ofAntibiotics (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Mariska KerstholtDepartment of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Hedwig VrijmoethDepartment of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Ekta LachmandasDepartment of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Marije OostingDepartment of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Mihaela LupseDepartment of Infectious Diseases, University of Medicine and Pharmacy "Iuliu Hatieganu," 400349 Cluj-Napoca, Romania.
Mirela FlontaDepartment of Infectious Diseases, University of Medicine and Pharmacy "Iuliu Hatieganu," 400349 Cluj-Napoca, Romania.
Charles A DinarelloDepartment of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands; leo.joosten@radboudumc.nl cdinare333@aol.com.
Mihai G NeteaDepartment of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Leo A B JoostenDepartment of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands; leo.joosten@radboudumc.nl cdinare333@aol.com.
University Medical Center · USIuliu Hațieganu University of Medicine and Pharmacy · RORadboud University Medical Center · NLRadboud University Nijmegen · NL

Funding

Yeast-based HTS Assay Technologies for ProteasesR01AI015614 · NIAID · UNIVERSITY OF COLORADO DENVER · PI DINARELLO, CHARLES ANTHONY · 1985 to 2025
$8.5M
NIAID NIH HHS R01 AI015614
6 · The paper itself

Abstract

Pathogen-induced changes in host cell metabolism are known to be important for the immune response. In this study, we investigated how infection with the Lyme disease-causing bacterium

Indexed as

Borrelia burgdorferiCytokinesGlutathioneHost-Pathogen InteractionsHumansLyme DiseaseMonocytesReactive Oxygen SpeciesCytokinesGlutathioneReactive Oxygen SpeciesB. burgdorfericell metabolismglutathioneLyme disease

Identifiers

PMID29444855
PMCPMC5877983
OpenAlexW2792668303

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.