ArticleBMC neurology2018
Right-to-left shunt and subclinical ischemic brain lesions in Chinese migraineurs: a multicentre MRI study.
Article in BMC neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02425696 (Registry of Right-to-left Shunt Detection by Contrast-enhanced Transcranial Doppler in Chinese Population), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Registry of Right-to-left Shunt Detection by Contrast-enhanced Transcranial Doppler in Chinese Population
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Evaluating the relationship between right-to-left shunt and white matter hyperintensities in migraine patients: A systematic review and meta-analysis.Frontiers in neurology · 2022Pooled it
- Analysis of the relationships between the degree of migraine with right-to-left shunts and changes in white matter lesions and brain structural volume.Scientific reports · 2025Article
- White matter hyperintensity burden in young patent foramen ovale patients and its correlation with migraine.Frontiers in neurology · 2025Article
- The novel imaging methods in diagnosis and assessment of cerebrovascular diseases: an overview.Frontiers in medicine · 2024Review
- Relationship between right-to-left shunt and white matter lesions in patients with migraine: a single-center study.Frontiers in neurology · 2024Article
- Recent progress in patent foramen ovale and related neurological diseases: A narrative review.Frontiers in neurology · 2023Review
- The Patent Foramen Ovale and Migraine: Associated Mechanisms and Perspectives from MRI Evidence.Brain sciences · 2022Review
- Small Demyelination of the Cortex May Be a Potential Marker for the Right-to-Left Shunt of the Heart.Brain sciences · 2022Article
- Right-to-left shunts in unexplained syncope: an age- and sex-matched case-control study.Quantitative imaging in medicine and surgery · 2022Article
- Right-to-left shunts and hormonal therapy influence cerebral vasomotor reactivity in patients with migraine with aura.PloS one · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMigraine is considered as a risk factor for subclinical brain ischemic lesions, and right-to-left shunt (RLS) is more common among migraineurs. This cross-sectional study assessed the association of RLS with the increased prevalence of subclinical ischemic brain lesions in migraineurs.
methodsWe enrolled 334 migraineurs from a multicentre study from June 2015 to August 2016. Participants were all evaluated using contrast-enhanced transcranial Doppler, magnetic resonance imaging (MRI), and completed a questionnaire covering demographics, the main risk factors of vascular disease, and migraine status. RLS was classified into four grades (Grade 0 = Negative; Grade I = 1 ≤ microbubbles (MBs) ≤ 10; Grade II = MBs > 10 and no curtain; Grade III = curtain). Silent brain ischemic infarctions (SBI) and white matter hyperintensities (WMHs) were evaluated on MRI.
resultsWe found no significant differences between migraineurs with RLS and migraineurs without RLS in subclinical ischemic brain lesions.SBI and WMHs did not increase with the size of the RLS(p for trend for SBI = 0.066, p for trend for WMHs = 0.543). Furthermore, curtain RLS in migraineurs was a risk factor for the presence of SBI (p = 0.032, OR = 3.47; 95%CI: 1.12-10.76). There was no association between RLS and the presence of WMHs.
conclusionOverall, RLS is not associated with increased SBI or WMHs in migraineurs. However, when RLS is present as a curtain pattern, it is likely to be a risk factor for SBIs in migraineurs.
trial registrationNo. NCT02425696 ; registered on April 21, 2015.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.