ArticleBMC microbiology2018
Transcriptome analysis of different growth stages of Aspergillus oryzae reveals dynamic changes of distinct classes of genes during growth.
Article in BMC microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Genomic and physiological signatures of adaptation in pathogenic fungi.Nature communications · 2026Article
- Transcriptomic Analysis ofMicroorganisms · 2026Article
- The Velvet protein vea: a key positive regulator of growth and cordycepin biosynthesis in Cordyceps militaris.Microbial cell factories · 2025Article
- The cyclase-associated protein contributes to antifungal susceptibility and virulence inEmerging microbes & infections · 2025Article
- Impact ofFoods (Basel, Switzerland) · 2025Article
- Identification and functional analysis of the SET domain-containing gene family in Cordyceps militaris.Scientific reports · 2025Article
- Expression pattern, subcellular localization ofApplied and environmental microbiology · 2025Article
- AozC, a zn(II)Microbial cell factories · 2025Article
- Alanine supplementation enhancing cordycepin production in Cordyceps militaris via upregulation of Cns2 and Cns3 genes expression levels.Journal of food and drug analysis · 2024Article
- Advancements in Green Nanoparticle Technology: Focusing on the Treatment of Clinical Phytopathogens.Biomolecules · 2024Review
- The postbiotic potential ofFrontiers in microbiology · 2024Review
- Abalone Viscera Fermented withNutrients · 2023Article
- Integrative Analysis of Metabolome and Transcriptome Reveals the Mechanism of Color Formation in Yellow-Fleshed Kiwifruit.International journal of molecular sciences · 2023Article
- Article
- RNA-Seq Based Transcriptome Analysis ofJournal of fungi (Basel, Switzerland) · 2022Article
- Physiological and transcriptomic analyses revealed the change of main flavor substance ofFrontiers in nutrition · 2022Article
- Article
- The ancient koji mold (Aspergillus oryzae) as a modern biotechnological tool.Bioresources and bioprocessing · 2021Review
- Transcriptome sequencing revealed the mechanism of promoting floret opening by exogenous methyl jasmonate in sorghum.3 Biotech · 2021Article
- Transcriptomic Responses ofFrontiers in nutrition · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundThe gene expression profile and metabolic pathways of Aspergillus oryzae underlying the anatomical and morphological differentiation across different growth stages have not been fully characterized. The rapid development of next-generation sequencing technologies provides advanced knowledge of the genomic organization of A. oryzae.
resultsIn this study, we characterized the growth and development of A. oryzae at different growth stages, including the adaptive phase, logarithmic phase, and stationary phase. Our results revealed that A. oryzae undergoes physiological and morphological differentiation across the different stages. RNA-seq was employed to analyze the three stages of A. oryzae, which generated more than 27 million high-quality reads per sample. The analysis of differential gene expression showed more genes expressed differentially upon transition from the adaptive phase to the logarithmic and stationary phases, while relatively steady trend was observed during the transition from the logarithmic phase to the stationary phase. GO classification of the differentially expressed genes among different growth stages revealed that most of these genes were enriched for single-organism process, metabolic process, and catalytic activity. These genes were then subjected to a clustering analysis. The results showed that the cluster with the majority of genes with increased expression upon transition from the adaptive phase to the logarithmic phase, and steady expression from the logarithmic phase to the stationary phase was mainly involved in the carbohydrate and amino acid metabolism.
conclusionOur results provide a foundation for identifying developmentally important genes and understanding the biological processes across various growth stages.
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