Evidence map›Paper›PMID 29444614›Full record

ArticleThe Journal of international medical research2018

In vitro anti-influenza virus effect of total flavonoid from Trollius ledebouri Reichb.

Yongping Liu, Jiming Tong, Ying Tong, Ping Li, Xiaolan Cui, Hongbao Cao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yongping Liu1 Laboratory of Pharmacology and Toxicology of Key Laboratory for Research and Development of Chinese Materia Medica in Hebei Province, China; Department of Pharmacology and Toxicology, Institute of Chinese Materia Medica, 92979 Chengde Medical University , China.
Jiming Tong1 Laboratory of Pharmacology and Toxicology of Key Laboratory for Research and Development of Chinese Materia Medica in Hebei Province, China; Department of Pharmacology and Toxicology, Institute of Chinese Materia Medica, 92979 Chengde Medical University , China.
Ying Tong2 Radiology Department, Affiliated Hospital of 92979 Chengde Medical University , Chengde, China.
Ping Li1 Laboratory of Pharmacology and Toxicology of Key Laboratory for Research and Development of Chinese Materia Medica in Hebei Province, China; Department of Pharmacology and Toxicology, Institute of Chinese Materia Medica, 92979 Chengde Medical University , China.
Xiaolan Cui3 Department of Pharmacology, 417459 Institute of Chinese Materia Medica, Chinese Academy of Chinese Medicine sciences , Beijing, China.
Hongbao Cao4 Department of Genomics Research, R&D Solutions, Elsevier Inc., Rockville, MD, USA.
Chengde Medical University · CNChina Academy of Chinese Medical Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective To investigate the in vitro antivirus effect of total flavonoid from Trollius ledebouri Reichb (TFTLR). Methods Madin-Darby canine kidney (MDCK) and Human epithelial type 2 (HEp-2) cell lines were used to test the antivirus effect of TFTLR on nine virus subtypes: four H1N1, one H3N2, and four other subtypes prevalent in North China. Tamiflu, Ribavirin and Lianhua Qingwen were used as active comparators. Comprehensive molecular pathway analyses of TFTLR-H1N1 and TFTLR-H3N2 relationships were also conducted. Results TFTLR inhibited MDCK cell lesions induced by H1N1 subtypes (A/FM1/1/47, A/Puerto Rico/8/1934 H1N1, A1/Tianjin Jinnan/15/2009, and A/Brisbane/59/2007) and by the H3N2 Brisbane/10/2009 strain. TFTLR inhibitory concentration (IC)

Indexed as

AnimalsAntiviral AgentsDogsFlavonoidsHumansInhibitory Concentration 50Madin Darby Canine Kidney CellsOrthomyxoviridaeRanunculaceaeSignal TransductionAntiviral AgentsFlavonoidsinfluenza A viruspathway analysisrespiratory virusT. ledebouri ReichbTotal flavonoid

Identifiers

PMID29444614
PMCPMC6091840
OpenAlexW2789167733

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.