ArticleActa paediatrica (Oslo, Norway : 1992)2018
Long-chain polyunsaturated fatty acids decline rapidly in milk from mothers delivering extremely preterm indicating the need for supplementation.
Article in Acta paediatrica (Oslo, Norway : 1992), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Total Fat and Fatty Acid Composition of Preterm Human Milk: A Systematic Review and Meta-analysis.Advances in nutrition (Bethesda, Md.) · 2026Pooled it
- Long-chain polyunsaturated fatty acids supplementation and sepsis: a systematic review and meta-analysis.Pediatric research · 2025Pooled it
- Modification of serum fatty acids in preterm infants by parenteral lipids and enteral docosahexaenoic acid/arachidonic acid: A secondary analysis of the Mega Donna Mega trial.Clinical nutrition (Edinburgh, Scotland) · 2023Trial
- Influence of Human Milk and Parenteral Lipid Emulsions on Serum Fatty Acid Profiles in Extremely Preterm Infants.JPEN. Journal of parenteral and enteral nutrition · 2019Trial
- Neurofilament light chain associates with IVH and ROP in extremely preterm infants.Pediatric research · 2025Article
- Changes in the Fatty Acid Profile of Lactating Women Living in Poland-A Comparison with the Fatty Acid Profile of Selected Infant Formulas.Nutrients · 2024Article
- Comparative study of the digestion and metabolism related genes' expression changes during the postnatal food change in different dietary mammals.Frontiers in genetics · 2023Article
- Comparative Analysis of Docosahexaenoic Acid (DHA) Content in Mother's Milk of Term and Preterm Mothers.Nutrients · 2022Observational
- Randomized controlled trial of early arachidonic acid and docosahexaenoic acid enteral supplementation in very preterm infants.Frontiers in pediatrics · 2022Article
- Metabolism in Retinopathy of Prematurity.Life (Basel, Switzerland) · 2021Review
- Sphingolipidomics of serum in extremely preterm infants: Association between low sphingosine-1-phosphate levels and severe retinopathy of prematurity.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2021Article
- GGPP depletion initiates metaflammation through disequilibrating CYB5R3-dependent eicosanoid metabolism.The Journal of biological chemistry · 2020Article
- Lipid profiling of suction blister fluid: comparison of lipids in interstitial fluid and plasma.Lipids in health and disease · 2019Article
- Quantification of Human Milk Phospholipids: the Effect of Gestational and Lactational Age on Phospholipid Composition.Nutrients · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
aimOur aim was to perform an in-depth analysis of the composition of fatty acids in milk from mothers delivering extremely preterm babies. We investigated longitudinal changes in milk fatty acid profiles and the relationship between several types of fatty acids, including omega-3 and omega-6.
methodsMilk samples were collected at three stages of lactation from 78 mothers who delivered at less than 28 weeks of pregnancy at the Sahlgrenska University Hospital, Gothenburg, Sweden, from April 2013 to September 2015. Fatty acid composition was analysed by gas chromatography-mass spectrometry.
resultsA reduction in long-chain polyunsaturated fatty acids (LCPUFAs) was observed during the lactation period. The concentrations of arachidonic acid and docosahexaenoic acid declined from medians of 0.34 to 0.22 mol% and 0.29 to 0.15 mol%, respectively, between postnatal day 7 and a postmenstrual age of 40 weeks. Strong correlations were found between the intermediates of several classes of fatty acids, including omega-3, omega-6 and omega-9.
conclusionA rapid reduction in LCPUFA content in the mother's milk during the lactation period emphasises the importance of fatty acid supplementation to infants born extremely preterm, at least during the period corresponding to the third trimester, when rapid development of the brain and adipose tissue requires high levels of LCPUFAs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.