Evidence map›Paper›PMID 29444163›Full record

ArticlePloS one2018

The effect of "NutramilTM Complex," food for special medical purpose, on breast and prostate carcinoma cells.

Aneta A Koronowicz, Mariola Drozdowska, Barbara Wielgos, Ewelina Piasna-Słupecka, Dominik Domagała, Joanna Dulińska-Litewka, Teresa Leszczyńska

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Aneta A KoronowiczDepartment of Human Nutrition, Faculty of Food Technology, University of Agriculture, Krakow, Poland.ORCID 0000-0002-1653-2867
Mariola DrozdowskaDepartment of Human Nutrition, Faculty of Food Technology, University of Agriculture, Krakow, Poland.
Barbara WielgosOlimp Laboratories sp. z o.o., Dębica, Poland.
Ewelina Piasna-SłupeckaDepartment of Human Nutrition, Faculty of Food Technology, University of Agriculture, Krakow, Poland.
Dominik DomagałaDepartment of Human Nutrition, Faculty of Food Technology, University of Agriculture, Krakow, Poland.
Joanna Dulińska-LitewkaChair of Medical Biochemistry, Jagiellonian University Medical College, Kraków, Poland.
Teresa LeszczyńskaDepartment of Human Nutrition, Faculty of Food Technology, University of Agriculture, Krakow, Poland.
University of Agriculture in Krakow · PLJagiellonian University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NutramilTM Complex is a multicomponent food product that meets the requirements of a food for special medical purpose. As a complete, high-energy diet it consists of properly balanced nutrients, vitamins and minerals. The aim of this study was to assess the effect of NutramilTM Complex on breast and prostate carcinoma cells. Our results showed that NutramilTM Complex reduced the viability and proliferation of breast and prostate cancer cells and that this process was associated with the induction of apoptosis via activation of caspase signalling. Data showed elevated levels of p53 tumour suppressor, up-regulation of p38 MAPK and SAPK / JNK proteins and downregulation of anti-apoptotic ERK1/2, AKT1 and HSP27. Treatment with NutramilTM Complex also affected the expression of the BCL2 family genes. Results also showed down-regulation of anti-apoptotic BCL-2 and up-regulation of pro-apoptotic members such as BAX, BAD, BID. In addition, we also observed regulation of many other genes, including Iκβα, Chk1 and Chk2, associated with apoptotic events. Taken together, our results suggest activation of the mitochondrial apoptotic pathway as most likely mechanism of anti-carcinogenic activity of NutramilTM Complex.

Indexed as

Foods, SpecializedAnticarcinogenic AgentsApoptosisBreast NeoplasmsCell Line, TumorCell ProliferationCell SurvivalFemaleFood, FortifiedGene ExpressionGenes, cdcHumansMaleMCF-7 CellsProstatic NeoplasmsRNA, MessengerAnticarcinogenic AgentsRNA, Messenger

Identifiers

PMID29444163
PMCPMC5812662
OpenAlexW2787312847

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.