ArticlePloS one2018
Probiotic and anti-inflammatory potential of Lactobacillus rhamnosus 4B15 and Lactobacillus gasseri 4M13 isolated from infant feces.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 1 of them a synthesis that pooled it.
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Who cites it
108 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
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- In Vitro Characterization of Probiotic Properties of Lactobacillus Species Isolated from Boza Traditional Non-Alcoholic Fermented Turkish Beverage.Probiotics and antimicrobial proteins · 2026Article
- Associations of probiotics, prebiotics, synbiotics, and yogurt supplements with oxidative balance scores and all-cause and cardiovascular mortalities in neuropsychiatric disorders.American heart journal plus : cardiology research and practice · 2026Article
- Characterization of the Probiotic Properties and Cholesterol Metabolism Regulation Potential of Lactiplantibacillus plantarum QL-19.Probiotics and antimicrobial proteins · 2026Article
- Unlocking the probiotic potential of breast milk-derived lactobacillus against urinary tract infections: mechanisms, therapeutic prospects, and future directions.Antonie van Leeuwenhoek · 2026Review
- Hypolipidemic activity of Limosilactobacillus fermentum SHY0004 from Miao sour soup.BMC microbiology · 2026Article
- Genomic and phenotypic analysis ofFrontiers in microbiology · 2026Article
- The impacts of native potential probiotic cocktail to prevent or ameliorate inflammation by targeting autophagy signalling pathway.Journal of nutritional science · 2026Article
- Safety Evaluation of Human-Derived Uric Acid Degrading Lacticaseibacillus paracasei M2a and Its Impact on Gut Microbiota.Probiotics and antimicrobial proteins · 2026Article
- Article
- Novel Probiotic Candidates in Artisanal Feta-Type Kefalonian Cheese: Unveiling a Still-Undisclosed Biodiversity.Probiotics and antimicrobial proteins · 2025Article
- Probiotic Potentials and Protective Effects ofNutrients · 2025Article
- Extracellular vesicles derived from Lactobacillus gasseri GFC-1220 alleviate inflammation via the TLR4/NF-κB signaling pathway in LPS-stimulated RAW264.7 macrophages.Scientific reports · 2025Article
- Synbiotic pineapple beverage increases life span in Caenorhabditis elegans, ameliorates cognitive impairment, and restores gut microbiome diversity in D-galactose-induced aged C57BL/6 mice.Biogerontology · 2025Article
- Modulation of Macrophages TLR4-Mediated Transcriptional Response byInternational journal of molecular sciences · 2025Article
- Profiling the response of individual gut microbes to free fatty acids (FFAs) found in human milk.Journal of functional foods · 2025Article
48 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A total of 22 Lactobacillus strains, which were isolated from infant feces were evaluated for their probiotic potential along with resistance to low pH and bile salts. Eight isolates (L. reuteri 3M02 and 3M03, L. gasseri 4M13, 4R22, 5R01, 5R02, and 5R13, and L. rhamnosus 4B15) with high tolerance to acid and bile salts, and ability to adhere to the intestine were screened from 22 strains. Further, functional properties of 8 Lactobacillus strains, such as anti-oxidation, inhibition of α-glucosidase activity, cholesterol-lowering, and anti-inflammation were evaluated. The properties were strain-specific. Particularly, two strains of L. rhamnosus, 4B15 (4B15) and L. gasseri 4M13 (4M13) showed considerably higher anti-oxidation, inhibition of α-glucosidase activity, and cholesterol-lowering, and greater inhibition of nitric oxide production than other strains. Moreover, the two selected strains substantially inhibited the release of inflammatory mediators such as TNF-α, IL-6, IL-1β, and IL-10 stimulated the treatment of RAW 264.7 macrophages with LPS. In addition, whole genome sequencing and comparative genomic analysis of 4B15 and 4M13 indicated them as novel genomic strains. These results suggested that 4B15 and 4M13 showed the highest probiotic potential and have an impact on immune health by modulating pro-inflammatory cytokines.
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