ArticlePloS one2018
Alpha desynchronization/synchronization during working memory testing is compromised in acute mild traumatic brain injury (mTBI).
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Management and Prognosis of Patients with Mild Traumatic Brain Injury: A Narrative Review.Brain sciences · 2026Review
- Non-linear and spectral EEG dynamics as stage-specific biomarkers of neuropsychological recovery post-stroke.Frontiers in neuroscience · 2026Article
- Neural correlates of fatigue after traumatic brain injury.Brain communications · 2025Article
- Disrupted brain functional connectivity as early signature in cognitively healthy individuals with pathological CSF amyloid/tau.Communications biology · 2024Article
- Neurophysiological signatures of mild traumatic brain injury in the acute and subacute phase.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Preliminary Observations of Personalized Repetitive Magnetic Stimulation (PrTMS) Guided by EEG Spectra for Concussion.Brain sciences · 2023Article
- Diagnostic Competence of Creatine Kinase BB, in Mild Traumatic Brain Injury and its Prognostic Value.Advanced biomedical research · 2023Article
- Alpha desynchronization during Stroop test unmasks cognitively healthy individuals with abnormal CSF Amyloid/Tau.Neurobiology of aging · 2022Article
- Task switching reveals abnormal brain-heart electrophysiological signatures in cognitively healthy individuals with abnormal CSF amyloid/tau, a pilot study.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2021Article
- Teasing apart trauma: neural oscillations differentiate individual cases of mild traumatic brain injury from post-traumatic stress disorder even when symptoms overlap.Translational psychiatry · 2021Article
- Searching for a traumatic brain injury biomarker to aid clinical decision making in the emergency department.EBioMedicine · 2020Article
- Compromised Behavior and Gamma Power During Working Memory in Cognitively Healthy Individuals With Abnormal CSF Amyloid/Tau.Frontiers in aging neuroscience · 2020Article
- Alpha desynchronization during simple working memory unmasks pathological aging in cognitively healthy individuals.PloS one · 2019Article
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Authors and funding
10 authors.
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Abstract
Diagnosing and monitoring recovery of patients with mild traumatic brain injury (mTBI) is challenging because of the lack of objective, quantitative measures. Diagnosis is based on description of injuries often not witnessed, subtle neurocognitive symptoms, and neuropsychological testing. Since working memory (WM) is at the center of cognitive functions impaired in mTBI, this study was designed to define objective quantitative electroencephalographic (qEEG) measures of WM processing that may correlate with cognitive changes associated with acute mTBI. First-time mTBI patients and mild peripheral (limb) trauma controls without head injury were recruited from the emergency department. WM was assessed by a continuous performance task (N-back). EEG recordings were obtained during N-back testing on three occasions: within five days, two weeks, and one month after injury. Compared with controls, mTBI patients showed abnormal induced and evoked alpha activity including event-related desynchronization (ERD) and synchronization (ERS). For induced alpha power, TBI patients had excessive frontal ERD on their first and third visit. For evoked alpha, mTBI patients had lower parietal ERD/ERS at the second and third visits. These exploratory qEEG findings offer new and non-invasive candidate measures to characterize the evolution of injury over the first month, with potential to provide much-needed objective measures of brain dysfunction to diagnose and monitor the consequences of mTBI.
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