Evidence map›Paper›PMID 29443942›Full record

Trial reportNutrients2018

Understanding the Effect of Particle Size and Processing on Almond Lipid Bioaccessibility through Microstructural Analysis: From Mastication to Faecal Collection.

Giuseppina Mandalari, Mary L Parker, Myriam M-L Grundy, Terri Grassby, Antonella Smeriglio, Carlo Bisignano, Roberto Raciti, Domenico Trombetta, David J Baer, Peter J Wilde

Open access · goldAbstract readComparative StudyRandomized Controlled TrialValidation Study
In one paragraph

Trial report in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Giuseppina MandalariDepartment of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, Viale SS. Annunziata, 98168 Messina, Italy. gmandalari@unime.it.
Mary L ParkerQuadram Institute Bioscience, Norwich NR4 7UA, UK. mary.parker@qibextra.co.uk.
Myriam M-L GrundyQuadram Institute Bioscience, Norwich NR4 7UA, UK. myriam.grundy@quadram.ac.uk.ORCID 0000-0001-7162-656X
Terri GrassbySchool of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK. t.grassby@surrey.ac.uk.ORCID 0000-0002-0658-9093
Antonella SmeriglioDepartment of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, Viale SS. Annunziata, 98168 Messina, Italy. asmeriglio@unime.it.ORCID 0000-0002-9756-304X
Carlo BisignanoDepartment of Biomedical, Dental, Morphological and Functional Images Sciences, University of Messina, Via C. Valeria, 98125 Messina, Italy. cbisignano@unime.it.
Roberto RacitiDepartment of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, Viale SS. Annunziata, 98168 Messina, Italy. rraciti@unime.it.
Domenico TrombettaDepartment of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, Viale SS. Annunziata, 98168 Messina, Italy. dtrombetta@unime.it.ORCID 0000-0003-4358-5224
David J BaerU.S. Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Centre, Building 307B, Room 213, BARC-East, Beltsville, MD 20705, USA. David.Baer@ARS.USDA.GOV.
Peter J WildeQuadram Institute Bioscience, Norwich NR4 7UA, UK. peter.wilde@quadram.ac.uk.
University of Messina · ITQuadram Institute · GBAgricultural Research Service · USUniversity of Surrey · GB

Funding

Biotechnology and Biological Sciences Research Council BB/H004866/1
6 · The paper itself

Abstract

We have previously reported on the low lipid bioaccessibility from almond seeds during digestion in the upper gastrointestinal tract (GIT). In the present study, we quantified the lipid released during artificial mastication from four almond meals: natural raw almonds (NA), roasted almonds (RA), roasted diced almonds (DA) and almond butter from roasted almonds (AB). Lipid release after mastication (8.9% from NA, 11.8% from RA, 12.4% from DA and 6.2% from AB) was used to validate our theoretical mathematical model of lipid bioaccessibility. The total lipid potentially available for digestion in AB was 94.0%, which included the freely available lipid resulting from the initial sample processing and the further small amount of lipid released from the intact almond particles during mastication. Particle size distributions measured after mastication in NA, RA and DA showed most of the particles had a size of 1000 µm and above, whereas AB bolus mainly contained small particles (<850 µm). Microstructural analysis of faecal samples from volunteers consuming NA, RA, DA and AB confirmed that some lipid in NA, RA and DA remained encapsulated within the plant tissue throughout digestion, whereas almost complete digestion was observed in the AB sample. We conclude that the structure and particle size of the almond meals are the main factors in regulating lipid bioaccessibility in the gut.

Indexed as

DefecationDigestionMasticationModels, BiologicalNutsPrunus dulcisCondimentsCookingCross-Over StudiesDietary FatsFecesFemaleFood HandlingFood StorageGastrointestinal ContentsHumansDietary Fatsalmondslipid bioaccessibilitymicrostructural analysisparticle size

Identifiers

PMID29443942
PMCPMC5852789
OpenAlexW2789248433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.