SynthesisMedicine2018
Association of human leukocyte antigen (HLA)-DQ and HLA-DQA1/DQB1 alleles with Vogt-Koyanagi-Harada disease: A systematic review and meta-analysis.
Synthesis in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Vogt-Koyanagi-Harada disease frequency around the globe: a systematic review and meta-analysis.Eye (London, England) · 2026Pooled it
- Squeaking in fourth-generation ceramic-on-ceramic total hip replacement and the relationship with prosthesis brands: meta-analysis and systematic review.Journal of orthopaedic surgery and research · 2018Pooled it
- Advances in the Study of the Pathogenesis of Vogt-Koyanagi- Harada Syndrome.Current molecular medicine · 2025Review
- Vogt-Koyanagi-Harada Disease and COVID.Journal of clinical medicine · 2023Review
- Successive onset of Vogt-Koyanagi-Harada syndrome in father and son.BMC ophthalmology · 2023Article
- Probable Vogt-Koyanagi-Harada Disease after COVID-19 Vaccination: Case Report and Literature Review.Vaccines · 2022Article
- Enriched and Decreased Intestinal Microbes in Active VKH Patients.Investigative ophthalmology & visual science · 2022Article
- Vogt Koyanagi Harada disease following a recent COVID-19 infection.Indian journal of ophthalmology · 2022Article
- Vogt-Koyanagi-Harada patients show higher frequencies of circulating NKG2DClinical and experimental immunology · 2021Article
- Vogt-Koyanagi-Harada disease in a Native American population in Oklahoma.International ophthalmology · 2021Article
- Vogt-Koyanagi-Harada Disease: A Case Series in a Tertiary Eye Center.Case reports in ophthalmological medicine · 2021Article
- Genetic variations in autoimmune genes and VKH disease.International ophthalmology · 2020Review
- Correlation between systemic inflammatory response and quality of life in patients with chronic rhinosinusitis.International forum of allergy & rhinology · 2019Observational
- Article
- Autoimmune vertigo: an update on vestibular disorders associated with autoimmune mechanisms.Immunologic research · 2018Review
- Vogt-Koyanagi-Harada Disease, a Rare Entity in Spain: The Challenge of Worldwide Immigration and Globalization.European journal of case reports in internal medicine · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to evaluate the association of human leukocyte antigen (HLA)-DQ and HLA-DQA1/DQB1 alleles with Vogt-Koyanagi-Harada (VKH), providing further evidences on the genetic background of this disease.
methodsA comprehensive literature search was conducted on the relationship of HLA-DQ and/or HLA-DQA1/DQB1 alleles with VKH through PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, VIP, and databases for grey literature. The last search was in October 2017. Pooled odds ratio (OR) with 95% confidence interval (95% CI) was calculated from extracted data to access the strength of the association between a genotype and VKH.
resultsHLA-DQ4 was confirmed to increase the risk of VKH significantly (OR = 4.63, 95% CI: 1.74-12.31, P = .002), while HLA-DQ1 seemed to reduce VKH occurrence with OR = 0.32 (95% CI: 0.22-0.47, P < .00001). HLA-DQA1*0301-(OR = 4.52, 95% CI: 1.42-14.35, P = .01) and HLA-DQB1*0401-(OR = 23.12, 95% CI: 11.54-46.31, P < .00001) positive patients probably had a rising tendency to suffer from VKH. Alleles including HLA-DQA1*0103, 0401, 0501 and HLA-DQB1*0301, 0402, 0601, 0603 were significant protective genetic factors.
conclusionWe concluded that HLA-DQ4 carriers had a higher risk of VKH and HLA-DQ1 seemed to be protective. People with positive HLA-DQA1*0301 and HLA-DQB1*0401 demonstrated to be more susceptible to VKH. HLA-DQA1*0103, 0401, 0501 and HLA-DQB1*0301, 0402, 0601, 0603 could be potential protectors.
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