ArticleBiomacromolecules2018
pH-Responsive Microencapsulation Systems for the Oral Delivery of Polyanhydride Nanoparticles.
Article in Biomacromolecules, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Fabrication and Anti-Swelling Properties of Gelatin/Sodium Alginate-Carboxymethyl Chitosan-Based Cationic Coordination Hydrogels.Foods (Basel, Switzerland) · 2025Article
- Shaping Orthodontics of the Future: Concepts and Implications from a Cellular and Molecular Perspective.International journal of molecular sciences · 2025Review
- Review
- Spray-Dried Powders of Casein-Encapsulated Rutin Stabilized With Sugars for the Enhancement of Intestinal Drug Solubility.Advances in pharmacological and pharmaceutical sciences · 2025Article
- Glycopolypeptide Coordinated Nanovaccine: Fabrication, Characterization, and Antitumor Immune Response.Chem & bio engineering · 2024Article
- Smart stimuli-responsive drug delivery systems in spotlight of COVID-19.Asian journal of pharmaceutical sciences · 2023Review
- Novel Hydrolytic Degradable Crosslinked Interpenetrating Polymeric Networks (IPNs): An Efficient Hybrid System to Manage the Controlled Release and Degradation of Misoprostol.Gels (Basel, Switzerland) · 2023Article
- Amikacin-Loaded Chitosan Hydrogel Film Cross-Linked with Folic Acid for Wound Healing Application.Gels (Basel, Switzerland) · 2023Article
- Polymer-Based Hydrogels Applied in Drug Delivery: An Overview.Gels (Basel, Switzerland) · 2023Review
- Research progress of stimulus-responsive antibacterial materials for bone infection.Frontiers in bioengineering and biotechnology · 2022Review
- Advanced biomedical hydrogels: molecular architecture and its impact on medical applications.Regenerative biomaterials · 2021Review
- Formation of Multicolor Nanogels Based on Cationic Polyfluorenes and Poly(methyl vinyl ether-alt-maleic monoethyl ester): Potential Use as pH-Responsive Fluorescent Drug Carriers.International journal of molecular sciences · 2021Article
- Preparation of Poly(ethylene glycol)@Polyurea Microcapsules Using Oil/Oil Emulsions and Their Application as Microreactors.Polymers · 2021Article
- Mesoporous Silica Nanoparticles Modified inside and out for ON:OFF pH-Modulated Cargo Release.Pharmaceutics · 2021Article
- Degradable polymeric vehicles for postoperative pain management.Nature communications · 2021Review
- Grafting with RAFT-gRAFT Strategies to Prepare Hybrid Nanocarriers with Core-shell Architecture.Polymers · 2020Article
- Microrheological characterization of covalent adaptable hydrogels for applications in oral delivery.Soft matter · 2019Article
- Engineered microscale hydrogels for drug delivery, cell therapy, and sequencing.Biomedical microdevices · 2019Review
- Oral Vaccine Delivery for Intestinal Immunity-Biological Basis, Barriers, Delivery System, and M Cell Targeting.Polymers · 2018Review
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
Abstract
Multicompartmental polymer carriers, referred to as Polyanhydride-Releasing Oral MicroParticle Technology (PROMPT), were formed by a pH-triggered antisolvent precipitation technique. Polyanhydride nanoparticles were encapsulated into anionic pH-responsive microparticle gels, allowing for nanoparticle encapsulation in acidic conditions and subsequent release in neutral pH conditions. The effects of varying the nanoparticle composition and feed ratio on the encapsulation efficiency were evaluated. Nanoparticle encapsulation was confirmed by confocal microscopy and infrared spectroscopy. pH-triggered protein delivery from PROMPT was explored using ovalbumin (ova) as a model drug. PROMPT microgels released ova in a pH-controlled manner. Increasing the feed ratio of nanoparticles into the microgels increased the total amount of ova delivered, as well as decreased the observed burst release. The cytocompatibility of the polymer materials were assessed using cells representative of the GI tract. Overall, these results suggest that pH-dependent microencapsulation is a viable platform to achieve targeted intestinal delivery of polyanhydride nanoparticles and their payload(s).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.