Evidence map›Paper›PMID 29443403›Full record

ReviewJPEN. Journal of parenteral and enteral nutrition2018

Proceedings of the 2017 ASPEN Research Workshop-Gastric Bypass: Role of the Gut.

Ajay Kumar Jain, Carel W le Roux, Puneet Puri, Ali Tavakkoli, Nana Gletsu-Miller, Blandine Laferrère, Richard Kellermayer, John K DiBaise, Robert G Martindale, Bruce M Wolfe

Open access · greenAbstract readReview
In one paragraph

Review in JPEN. Journal of parenteral and enteral nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 2 countries.

Ajay Kumar JainDepartment of Pediatrics, SSM Cardinal Glennon Children's Medical Center, Saint Louis University School of Medicine, Saint Louis, Missouri, USA.
Carel W le RouxDiabetes Complications Research Center, University College Dublin, School of Medicine, Dublin, Ireland.
Puneet PuriDivision of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, Vieginia, USA.
Ali TavakkoliBrigham and Women's Hospital, Center for Weight Management and Metabolic Surgery, Harvard Medical School, Boston, Massachusetts, USA.
Nana Gletsu-MillerNutrition Science, Purdue University, West Lafayette, Indiana, USA.
Blandine LaferrèreDepartment of Medicine, Division of Endocrinology, Columbia University, New York, New York, USA.
Richard KellermayerBaylor College of Medicine, Texas Children's Hospital, Houston, Texas, USA.
John K DiBaiseDivision of Gastroenterology and Hepatology, Mayo Clinic, Phoenix, Arizona, USA.
Robert G MartindaleOregon Health and Science University, Portland, Oregon, USA.
Bruce M WolfeOregon Health and Science University, Portland, Oregon, USA.
Oregon Health & Science University · USBaylor College of Medicine · USCardinal Glennon Children’s Medical Center · USColumbia University Irving Medical Center · USHarvard University · USMayo Clinic in Florida · USPurdue University West Lafayette · USUniversity College Dublin · IEVirginia Commonwealth University · US

Funding

Role of the bile acid activated receptors FXR and TGR5 in Total Parenteral Nutrition associated hepatic and gut diseaseK08DK098623 · NIDDK · SAINT LOUIS UNIVERSITY · PI JAIN, AJAY K. · 2016 to 2021
$821k
A.S.P.E.N. 2017 Research Workshop (RW) Gastric Bypass: Role of the GutR13DK109671 · NIDDK · AMERICAN SOCIETY/PARENT & ENTERAL NUTRIT · PI JAIN, AJAY K. · 2017 to 2017
$10k
NIDDK NIH HHS K08 DK098623NIDDK NIH HHS R13 DK109671
6 · The paper itself

Abstract

The goal of the National Institutes of Health-funded American Society for Parenteral and Enteral Nutrition 2017 research workshop (RW) "Gastric Bypass: Role of the Gut" was to focus on the exciting research evaluating gut-derived signals in modulating outcomes after bariatric surgery. Although gastric bypass surgery has undoubted positive effects, the mechanistic basis of improved outcomes cannot be solely explained by caloric restriction. Emerging data suggest that bile acid metabolic pathways, luminal contents, energy balance, gut mucosal integrity, as well as the gut microbiota are significantly modulated after bariatric surgery and may be responsible for the variable outcomes, each of which was rigorously evaluated. The RW served as a timely and novel academic meeting that brought together clinicians and researchers across the scientific spectrum, fostering a unique venue for interdisciplinary collaboration among investigators. It promoted engaging discussion and evolution of new research hypotheses and ideas, driving the development of novel ameliorative, therapeutic, and nonsurgical interventions targeting obesity and its comorbidities. Importantly, a critical evaluation of the current knowledge regarding gut-modulated signaling after bariatric surgery, potential pitfalls, and lacunae were thoroughly addressed.

Indexed as

Gastric BypassBile Acids and SaltsEnergy MetabolismGastrointestinal MicrobiomeHumansIntestinal MucosaObesityUnited StatesBile Acids and Saltsbariatric surgerydiabetesendocrinologyliver diseasemetabolic syndromemicrobiomeobesity

Identifiers

PMID29443403
PMCPMC5955776
OpenAlexW2793471017

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.