ArticleJournal of visualized experiments : JoVE2018
Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus.
Article in Journal of visualized experiments : JoVE, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Adipose-derived stem cells applied to ankle pathologies: a systematic review.Musculoskeletal surgery · 2024Pooled it
- Progress in the clinical use of bone marrow aspirate concentrate for knee osteoarthritis: an expert opinion.Journal of orthopaedic surgery and research · 2025Review
- Fat Harvesting for Micro-Fragmented Adipose Tissue Injections: A Pilot Study Comparing Safety in Procedures Performed by Orthopedic and Plastic Surgeons.Revista brasileira de ortopedia · 2025Article
- [Fat Harvesting for Micro-Fragmented Adipose Tissue Injections: A Pilot Study Comparing Safety in Procedures Performed by Orthopedic and Plastic Surgeons].Revista brasileira de ortopedia · 2025Article
- Micro-fragmented adipose tissue-An innovative therapeutic approach: A narrative review.Medicine · 2025Review
- Article
- Autologous micro-fragmented adipose tissue injection provides significant and prolonged clinical improvement in patients with knee osteoarthritis: a case-series study.Journal of experimental orthopaedics · 2023Article
- Minimally manipulated adipose derived mesenchymal stromal cells and osteoarthritis: A narrative review.Acta bio-medica : Atenei Parmensis · 2022Review
- Surgical treatment for insertional Achilles tendinopathy and retrocalcaneal bursitis: more than 1 year of follow-up.The Journal of international medical research · 2021Article
- Adipose-Derived Mesenchymal Stem Cell Treatments and Available Formulations.Current reviews in musculoskeletal medicine · 2020Review
- Patient-Centered Outcomes of Microfragmented Adipose Tissue Treatments of Knee Osteoarthritis: An Observational, Intention-to-Treat Study at Twelve Months.Stem cells international · 2020Article
- Osteochondral lesions of the talus: are we ready for metal?Annals of translational medicine · 2018Article
- Clinical Protocol of Producing Adipose Tissue-Derived Stromal Vascular Fraction for Potential Cartilage Regeneration.Journal of visualized experiments : JoVE · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, regenerative techniques have been increasingly studied and used to treat osteochondral lesions of the talus. In particular, several studies have focused their attention on mesenchymal stem cells derived from adipose tissue. Adipose-derived stem cells (ADSCs) exhibit morphological characteristics and properties similar to other mesenchymal cells, and are able to differentiate into several cellular lines. Moreover, these cells are also widely available in the subcutaneous tissue, representing 10 - 30% of the normal body weight, with a concentration of 5,000 cells per gram of tissue. In the presented technique, the first step involves harvesting ADSCs from the abdomen and a process of microfracture and purification; next, the surgical procedure is performed entirely arthroscopically, with less soft tissue dissection, better joint visualization, and a faster recovery compared with standard open procedures. Arthroscopy is characterized by a first phase in which the lesion is identified, isolated, and prepared with microperforations; the second step, performed dry, involves injection of adipose tissue at the level of the lesion. Between January 2016 and September 2016, four patients underwent arthroscopic treatment of osteochondral lesion of the talus with microfractured and purified adipose tissue. All patients reported clinical improvement six months after surgery with no reported complications. Functional scores at the latest follow-up are encouraging and confirm that the technique provides reliable pain relief and improvements in patients with osteochondral lesion of the talus.
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Registered trials
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