Evidence map›Paper›PMID 29442548›Full record

ReviewAmerican journal of physiology. Renal physiology2018

Mechanisms of altered renal sodium handling in age-related hypertension.

Alissa A Frame, Richard D Wainford

Open access · bronzeAbstract readReview
In one paragraph

Review in American journal of physiology. Renal physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Frequency of adding salt is a stronger predictor of chronic kidney disease in individuals with genetic risk.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Central GαiFrontiers in endocrinology · 2022
    Review
  10. Review
  11. Article
  12. Review
  13. Renal Dopamine Oxidation and Inflammation in High Salt Fed Rats.Journal of the American Heart Association · 2020
    Article
  14. The Influence of Dietary Salt Beyond Blood Pressure.Current hypertension reports · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alissa A FrameDepartment of Pharmacology and Experimental Therapeutics, Boston University School of Medicine and The Whitaker Cardiovascular Institute , Boston, Massachusetts.
Richard D WainfordDepartment of Pharmacology and Experimental Therapeutics, Boston University School of Medicine and The Whitaker Cardiovascular Institute , Boston, Massachusetts.
Boston University · US

Funding

TRAINING IN BIOMOLECULAR PHARMACOLOGYT32GM008541 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FARB, DAVID H · 1997 to 2022
$5.2M
Brain G-alpha subunit protein mediated neural control of blood pressureR01HL107330 · NHLBI · LSU HEALTH SCIENCES CENTER · PI WAINFORD, RICHARD DAVID · 2011 to 2015
$1.9M
Brain G-alpha subunit protein mediated neural control of blood pressureK02HL112718 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WAINFORD, RICHARD DAVID · 2013 to 2017
$577k
Renal and Neural Mechanisms of Age-Related HypertensionF31DK116501 · NIDDK · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FRAME, ALISSA A · 2017 to 2018
$92k
NHLBI NIH HHS K02 HL112718NHLBI NIH HHS R01 HL107330NIDDK NIH HHS F31 DK116501NIGMS NIH HHS T32 GM008541
6 · The paper itself

Abstract

The prevalence of hypertension rises with age to approximately two out of three adults over the age of 60 in the United States. Although the mechanisms underlying age-related hypertension are incompletely understood, sodium homeostasis is critical to the long-term regulation of blood pressure and there is strong evidence that aging is associated with alterations in renal sodium handling. This minireview focuses on recent advancements in our understanding of the vascular, neurohumoral, and renal mechanisms that influence sodium homeostasis and promote age-related hypertension.

Indexed as

AgingBlood PressureAge FactorsAnimalsFemaleHumansHypertensionKidneyMaleMiddle AgedRenal EliminationRenal ReabsorptionRenin-Angiotensin SystemRisk FactorsSodiumSympathetic Nervous SystemSodiumaginghypertensionrenal sodium handling

Identifiers

PMID29442548
PMCPMC6087788
OpenAlexW2786372200

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.