Evidence map›Paper›PMID 29442271›Full record

ArticleBrain imaging and behavior2018

Exploring variability in basal ganglia connectivity with functional MRI in healthy aging.

Ludovica Griffanti, Philipp Stratmann, Michal Rolinski, Nicola Filippini, Enikő Zsoldos, Abda Mahmood, Giovanna Zamboni, Gwenaëlle Douaud, Johannes C Klein, Mika Kivimäki and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain imaging and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Trial
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  14. Imaging the aged brain: pertinence and methods.Quantitative imaging in medicine and surgery · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ludovica GriffantiCentre for the functional MRI of the Brain (FMRIB), Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-0540-9353
Philipp StratmannDepartment of Psychiatry, University of Oxford, Oxford, UK.
Michal RolinskiOxford Parkinson's Disease Centre (OPDC), Oxford, UK.
Nicola FilippiniCentre for the functional MRI of the Brain (FMRIB), Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Enikő ZsoldosDepartment of Psychiatry, University of Oxford, Oxford, UK.
Abda MahmoodDepartment of Psychiatry, University of Oxford, Oxford, UK.
Giovanna ZamboniCentre for the functional MRI of the Brain (FMRIB), Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Gwenaëlle DouaudCentre for the functional MRI of the Brain (FMRIB), Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Johannes C KleinCentre for the functional MRI of the Brain (FMRIB), Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Mika KivimäkiDepartment of Epidemiology and Public Health, University College London, London, UK.
Archana Singh-ManouxDepartment of Epidemiology and Public Health, University College London, London, UK.
Michele T HuOxford Parkinson's Disease Centre (OPDC), Oxford, UK.
Klaus P EbmeierDepartment of Psychiatry, University of Oxford, Oxford, UK.
Clare E MackayOxford Parkinson's Disease Centre (OPDC), Oxford, UK. clare.mackay@ohba.ox.ac.uk.ORCID http://orcid.org/0000-0001-6111-8318

Funding

Education, socioeconomic status and Aging: transitions from multimorbidity to functional limitations and mortalityR01AG056477 · NIA · UNIVERSITY COLLEGE LONDON · PI KIVIMAKI, MIKA J, SINGH-MANOUX, ARCHANA · 2018 to 2022
$2.8M
Role of mid- and late-life risk factors in social inequalities in Alzheimer's Disease and Related DementiasRF1AG062553 · NIA · INSERM PARIS 5 · PI KIVIMAKI, MIKA J, SINGH-MANOUX, ARCHANA · 2019 to 2019
$1.5M
Gordon Edward Small's Charitable Trust SC008962Medical Research Council G1001354Medical Research Council MC_EX_MR/N50192X/1Medical Research Council MR/K006673/1Medical Research Council MR/K013351/1Medical Research Council MR/L023784/1Medical Research Council MR/M024962/1Medical Research Council (GB) G1001354National Institute for Health Research Biomedical Research Centre based at Oxford University Hospitals NHS Trust and University of OxfordNIA NIH HHS R01 AG056477NordForsk and the Academy of Finland 311492Parkinson's UK J-0901Parkinson's UK Monument Trust Discovery AwardWellcome Trust
6 · The paper itself

Abstract

Changes in functional connectivity (FC) measured using resting state fMRI within the basal ganglia network (BGN) have been observed in pathologies with altered neurotransmitter systems and conditions involving motor control and dopaminergic processes. However, less is known about non-disease factors affecting FC in the BGN. The aim of this study was to examine associations of FC within the BGN with dopaminergic processes in healthy older adults. We explored the relationship between FC in the BGN and variables related to demographics, impulsive behavior, self-paced tasks, mood, and motor correlates in 486 participants in the Whitehall-II imaging sub-study using both region-of-interest- and voxel-based approaches. Age was the only correlate of FC in the BGN that was consistently significant with both analyses. The observed adverse effect of aging on FC may relate to alterations of the dopaminergic system, but no unique dopamine-related function seemed to have a link with FC beyond those detectable in and linearly correlated with healthy aging.

Indexed as

AffectAgedAged, 80 and overBasal GangliaBrain MappingFemaleHealthy AgingHumansImpulsive BehaviorMaleMiddle AgedMotor ActivityNeural PathwaysRestSleepBasal gangliaDopamineFunctional connectivityHealthy agingParkinson’s diseaseResting state fMRI

Identifiers

PMID29442271
PMCPMC6302142

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.