ArticleGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2018
Two-point measurement of amylase in drainage fluid predicts severe postoperative pancreatic fistula after gastric cancer surgery.
Article in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 29 citations in OpenAlex.
- A Randomized Phase II Study to Evaluate Prolonged Prophylactic Antibacterial Drug Treatment for Patients with Elevated Drain Amylase Concentration After Gastrectomy with D2 Lymph Node Dissection (REDUCED2).World journal of surgery · 2021Trial
- Evaluation of efficacy of a polyglycolic acid sheet in laparoscopic gastrectomy for gastric cancer: a single-center retrospective study.BMC gastroenterology · 2026Article
- Clinical significance of intraoperative amylase levels on intra-abdominal exudates in the prediction of postoperative drain amylase levels after gastric cancer surgery.Langenbeck's archives of surgery · 2026Article
- Article
- Risk factors as criteria for drain use in gastrectomy: A prospective study.Molecular and clinical oncology · 2025Article
- Predictive model for pancreatic fistula in minimally invasive surgery for gastric cancer.Surgical endoscopy · 2025Article
- Risk assessment for pancreatic fistula by intraoperative image analysis of laparoscopic and robotic gastrectomy.Surgical endoscopy · 2024Article
- Usefulness of Bacterial Culture of Drainage Fluid for Predicting Surgical Site Infection After Crohn's Disease Surgery.Annals of gastroenterological surgery · 2022Article
- Drain Amylase Concentrations at 3 h After Gastrectomy Enhance Early Prediction of Postoperative Peripancreatic Inflammatory Fluid Collection.World journal of surgery · 2022Article
- Postoperative complications after a transthoracic esophagectomy or a transhiatal gastrectomy in patients with esophagogastric junctional cancers: a prospective nationwide multicenter study.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2022Article
- Optimal Timing to Assess Drain Amylase Concentration after Elective Gastrectomy.Journal of gastric cancer · 2021Article
- Pancreatic Fistula after D1+/D2 Radical Gastrectomy according to the Updated International Study Group of Pancreatic Surgery Criteria: Risk Factors and Clinical Consequences. Experience of Surgeons with High Caseloads in a Single Surgical Center in Eastern Europe.Journal of gastric cancer · 2021Article
- Postoperative pancreatic fistula after gastrectomy for gastric cancer.Annals of gastroenterological surgery · 2020Review
- Comparison of prognostic impact of anatomic location of the pancreas on postoperative pancreatic fistula in laparoscopic and open gastrectomy.BMC gastroenterology · 2020Article
- Is the measurement of drain amylase content useful for predicting pancreas-related complications after gastrectomy with systematic lymphadenectomy?World journal of gastroenterology · 2020Review
- Intraoperative Body Fluid Amylase as a Novel Indicator of Postgastrectomy Pancreatic Fistula.World journal of surgery · 2019Article
- Current status of the "enhanced recovery after surgery" program in gastric cancer surgery.Annals of gastroenterological surgery · 2019Review
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8 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundEarly identification of patients at risk of postoperative pancreatic fistula (POPF) allows appropriate management after gastrectomy. Although some reports have suggested a correlation between POPF and the concentration of amylase in drained abdominal fluid (D-AMY), this has not been proven to impact sufficiently on clinical decision-making. A sustained high level of D-AMY is often assumed to be due to unsatisfactory drainage or excessive pancreatic leakage. We assessed the clinical utility of measuring D-AMY on postoperative day (POD) 1 and POD3 for prediction of POPF.
methodsStarting in April 2014, 801 patients who underwent radical gastrectomy with prophylactic drain placement were consecutively enrolled. We routinely measured D-AMY on POD1 and POD3, and compared the incidence of problematic POPF and clinical factors including D-AMY. We also attempted to clarify whether such two-point D-AMY measurement was clinically useful for patient management after gastrectomy.
resultsFifty-one of the patients (6.4%) developed Clavien-Dindo grade III or worse POPF. Using D-AMY cutoffs of 2218 IU/L on POD1 and 555 IU/L on POD3, the patients were successfully classified. The highest risk group, in which D-AMY was higher than the cut-off value on both POD1 and POD3, showed a significantly high rate of occurrence (33/105, 31.4%) and high positive likelihood ratio (6.74). Multivariate analysis showed that classification into this highest risk group was an independent risk factor for development of severe POPF (odds ratio 15.2, 95% CI 7.92-29.0).
conclusionTwo-point measurement of D-AMY may be an efficient tool for achieving individualized management of POPF following radical gastrectomy.
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