Evidence map›Paper›PMID 29442221›Full record

ArticlePathology oncology research : POR2019

Dual-Stained Cervical Cytology and Histology with Claudin-1 and Ki67.

Tímea Szekerczés, Ádám Galamb, Adrienn Kocsis, Márta Benczik, Tibor Takács, Attila Martonos, Balázs Járay, András Kiss, Csaba Jeney, Miklós Nyíri and 2 more

Abstract read
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In one paragraph

Article in Pathology oncology research : POR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tímea Szekerczés2nd Department of Pathology, Semmelweis University, Üllői út 93, Budapest, H-1091, Hungary.
Ádám Galamb2nd Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.
Adrienn KocsisCellcall Ltd., Budapest, Hungary.
Márta BenczikCellcall Ltd., Budapest, Hungary.
Tibor TakácsCellcall Ltd., Budapest, Hungary.
Attila Martonos2nd Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.
Balázs Járay2nd Department of Pathology, Semmelweis University, Üllői út 93, Budapest, H-1091, Hungary.
András Kiss2nd Department of Pathology, Semmelweis University, Üllői út 93, Budapest, H-1091, Hungary.
Csaba JeneyCellcall Ltd., Budapest, Hungary.
Miklós NyíriCellcall Ltd., Budapest, Hungary.
Zsuzsa Schaff2nd Department of Pathology, Semmelweis University, Üllői út 93, Budapest, H-1091, Hungary. schaff.zsuzsa@med.semmelweis-univ.hu.ORCID http://orcid.org/0000-0002-6429-8059
Gábor Sobel2nd Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.

Funding

Hungarian National Research and Development Fund NKFP_07_2-SPE-SAFE, Jedlik Ányos 2. subprogram KMR_12-1-2012-0032Hungarian National Research Foundation OTKA PD105019
6 · The paper itself

Abstract

Several biomarkers are in use to improve the sensitivity and specificity of cervical cancer screening. Previously, increased expression of tight junction protein claudin-1 (CLDN1) was detected in premalignant and malignant cervical lesions and applied for cytology screening. To improve the specificity, a double immunoreaction with CLDN1/Ki67 was developed in the recent study. Parallel p16/Ki67 (CINtec® PLUS) and CLDN1/Ki67 dual-stained cytology and histology were performed and compared. p16/Ki67 immunoreaction showed positivity in 317 out of 1596 smears with negativity in 1072 and unacceptable reactions in 207 samples. CLDN1/Ki67 dual staining was positive in 200 of 1358 samples, negative in 962, whereas 196 smears could not be evaluated due to technical reasons. Considering the high-grade squamous intraepithelial lesion cytology as gold standard, sensitivity of CLDN1/Ki67 reaction was 76%, specificity was 85.67%, while for p16/Ki67 sensitivity was 74% and specificity was 81.38%. Comparison of CLDN1/Ki67 and p16/Ki67 dual stainings showed the results of the two tests not to be significantly different. Analysing histological slides from 63 cases, the results of the two tests agreed perfectly. As conclusion the sensitivity and specificity proved to be similar using p16/Ki67 and CLDN1/Ki67 double immunoreactions both on LBC samples and on histological slides.

Indexed as

AdultBiomarkers, TumorClaudin-1CytodiagnosisEarly Detection of CancerFemaleHumansImmunohistochemistryKi-67 AntigenLiquid BiopsyMiddle AgedPapillomavirus InfectionsPrecancerous ConditionsSensitivity and SpecificityUterine Cervical DysplasiaUterine Cervical NeoplasmsBiomarkers, TumorClaudin-1CLDN1 protein, humanKi-67 AntigenMKI67 protein, humanCervical cancerClaudin-1/Ki67 immunochemistryClaudinsp16/Ki67 reaction

Identifiers

PMID29442221

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.