Evidence map›Paper›PMID 29442191›Full record

ArticleThe journal of headache and pain2018

Measurement and implications of the distance between the sphenopalatine ganglion and nasal mucosa: a neuroimaging study.

Joan Crespi, Daniel Bratbak, David Dodick, Manjit Matharu, Kent Are Jamtøy, Irina Aschehoug, Erling Tronvik

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of headache and pain, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05136625 (Sphenopalatine Ganglion Block and Pain Management in Neurosurgery), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05136625 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Sphenopalatine Ganglion Block and Pain Management in Neurosurgery

TypeinterventionalSponsorUniversity Hospital of FerraraRan2021 to 2024Enrolled84ConditionsPost Operative Pain, Craniofacial PainArmsSphenopalatine ganglion block, Standard Preparation
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Joan CrespiDepartment of Neurology, St Olav's University Hospital, Edvards Grieg's gate 8, 7030, Trondheim, Norway. Joan.crespi@ntnu.no.ORCID http://orcid.org/0000-0003-0471-4329
Daniel BratbakDepartment of Neuromedicine and Movement Science, NTNU (University of Science and Technology), Trondheim, Norway.
David DodickDepartment of Neuromedicine and Movement Science, NTNU (University of Science and Technology), Trondheim, Norway.
Manjit MatharuNational Hospital of Neurology and Neurosurgery, London, UK.
Kent Are JamtøyDepartment of Neuromedicine and Movement Science, NTNU (University of Science and Technology), Trondheim, Norway.
Irina AschehougDepartment of Neuromedicine and Movement Science, NTNU (University of Science and Technology), Trondheim, Norway.
Erling TronvikDepartment of Neurology, St Olav's University Hospital, Edvards Grieg's gate 8, 7030, Trondheim, Norway.
Norwegian University of Science and Technology · NONational Hospital for Neurology and Neurosurgery · GB

Funding

Samarbeidsorganet NTNU/St Olavs University hospital -
6 · The paper itself

Abstract

backgroundHistorical reports describe the sphenopalatine ganglion (SPG) as positioned directly under the nasal mucosa. This is the basis for the topical intranasal administration of local anaesthetic (LA) towards the sphenopalatine foramen (SPF) which is hypothesized to diffuse a distance as short as 1 mm. Nonetheless, the SPG is located in the sphenopalatine fossa, encapsulated in connective tissue, surrounded by fat tissue and separated from the nasal cavity by a bony wall. The sphenopalatine fossa communicates with the nasal cavity through the SPF, which contains neurovascular structures packed with connective tissue and is covered by mucosa in the nasal cavity. Endoscopically the SPF does not appear open. It has hitherto not been demonstrated that LA reaches the SPG using this approach.

methodsOur group has previously identified the SPG on 3 T-MRI images merged with CT. This enabled us to measure the distance from the SPG to the nasal mucosa covering the SPF in 20 Caucasian subjects on both sides (n = 40 ganglia). This distance was measured by two physicians. Interobserver variability was evaluated using the intraclass correlation coefficient (ICC).

resultsThe mean distance from the SPG to the closest point of the nasal cavity directly over the mucosa covering the SPF was 6.77 mm (SD 1.75; range, 4.00-11.60). The interobserver variability was excellent (ICC 0.978; 95% CI: 0.939-0.990, p < 0.001).

conclusionsThe distance between the SPG and nasal mucosa over the SPF is longer than previously assumed. These results challenge the assumption that the intranasal topical application of LA close to the SPF can passively diffuse to the SPG.

Indexed as

NeuroimagingAdministration, IntranasalAdultAgedAnalysis of VarianceAnesthetics, LocalFemaleHeadache DisordersHumansMaleMiddle AgedMigraine DisordersNasal MucosaPterygopalatine FossaSphenopalatine Ganglion BlockAnesthetics, LocalBlockIntranasalLocal anaestheticsPterygopalatine ganglionSphenopalatine ganglion

Identifiers

PMID29442191
PMCPMC5811417
OpenAlexW2789003494

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.