ArticleInternational journal of colorectal disease2018
Outcomes and prognostic factors of selective lateral pelvic lymph node dissection with preoperative chemoradiotherapy for locally advanced rectal cancer.
Article in International journal of colorectal disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 8 of them syntheses that pooled it.
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Who cites it
42 citing papers in PubMed, 8 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Impact of lateral lymph node dissection on urogenital function and surgical outcomes following neoadjuvant chemoradiotherapy and total mesorectal excision for rectal cancer: a systematic review and meta-analysis.Surgical endoscopy · 2026Pooled it
- The Korean Rectal Cancer Multidisciplinary Committee Clinical Practice Guidelines for Rectal Cancer version 2.0.Annals of coloproctology · 2026Guideline
- Efficacy and Safety of Radical Resection of RectalContrast media & molecular imaging · 2022Pooled it
- Rise and fall of total mesorectal excision with lateral pelvic lymphadenectomy for rectal cancer: an updated systematic review and meta-analysis of 11,366 patients.International journal of colorectal disease · 2021Pooled it
- Total mesorectal excision with and without lateral lymph node dissection: a systematic review of the literature.International journal of colorectal disease · 2020Pooled it
- Pooled it
- Total mesorectal excision plus lateral lymph node dissection vs TME on rectal cancer patients: a meta-analysis.International journal of colorectal disease · 2020Pooled it
- Lateral Pelvic Lymph Node Metastases in Rectal Cancer: A Systematic Review.World journal of surgery · 2019Pooled it
- Is Transanal total mesorectal excision (TME) as safe and effective as laparoscopic TME for low rectal cancer? A propensity score-matched analysis.Surgery today · 2026Article
- MRI features of lateral lymph nodes predicting lateral local recurrence and prognostic impact of lateral lymph node dissection in low rectal cancer.European radiology · 2026Article
- Article
- Evaluation of Short-Term Postoperative Outcomes of Lateral Lymph Node Dissection After Neoadjuvant Radiotherapy for Rectal Cancer Patients: The Early Learning Phase After Surgical Training in the Netherlands.Annals of surgical oncology · 2025Article
- MRI-based scoring systems for selective lateral lymph node dissection in locally advanced low rectal cancer after neoadjuvant chemoradiotherapy.European radiology · 2025Article
- Efficacy and long-term outcomes of abdominoperineal resection using transperineal total mesorectal excision approach for rectal cancer.Surgery today · 2025Article
- Development and Validation of Nomogram Models Incorporating the Inflammatory Nutritional Index CALLY for Predicting Survival in Locally Advanced Rectal Cancer After Neoadjuvant Chemoradiotherapy.Cancer management and research · 2025Article
- Deep learning based on MRI for assessing the prognostic value of lateral lymph nodes in rectal cancer.Frontiers in oncology · 2025Article
- The role of lateral pelvic lymph node dissection in advanced rectal cancer: a review of current evidence and outcomes.Annals of coloproctology · 2024Review
- The consequences of laparoscopic fascial space priority approach to lateral lymph node dissection on urinary and sexual functionality.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2023Article
- The modified Glasgow prognostic score is a reliable predictor of oncological outcomes in patients with rectal cancer undergoing neoadjuvant chemoradiotherapy.Scientific reports · 2023Article
- Patients younger than 40 years with colorectal cancer have a similar prognosis to older patients.International journal of colorectal disease · 2023Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe clinical significance of preoperative chemoradiotherapy (CRT) and lateral lymph node dissection (LLND) for locally advanced rectal cancer remains unclear. We have employed total mesorectal excision and selective LLND following preoperative CRT for patients with locally advanced rectal cancer. The validity of our strategy was evaluated.
methodsA total of 45 patients with locally advanced rectal cancer who underwent curative surgery after CRT from November 2005 to September 2016 were retrospectively analyzed. LLND was performed only for the patients with lateral lymph nodes suspected to have metastasis based on the pretreatment images.
resultsRates of 5-year overall survival (OS) and 5-year relapse-free survival (RFS) were 85.7 and 61.8%, respectively. Univariate and multivariate analyses detected only histological response (grades 2 and 3 vs. grade 1) as a significant prognostic factor for OS and local recurrence. ypN and ypStage were significant factors for RFS by univariate analysis, while no significant factor was detected by multivariate analysis. There was no significant factor for distant recurrence. In good responders (grades 2 and 3), the local recurrence rate was 0% (P = 0.006, vs. grade 1), while distant recurrence developed in 4 of 20 cases (20%, P = 0.615, vs. grade 1). There was no local recurrence in LLND (-) group regardless the histological response.
conclusionsAlthough selective LLND with preoperative CRT seems effective and valid for good responders, new treatment strategy is necessary for poor responders. Therefore, development of reliable biomarkers for histological response to CRT is an urgent need.
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