Evidence map›Paper›PMID 29441677›Full record

ArticleJournal of cellular and molecular medicine2018

A novel susceptibility locus in MST1 and gene-gene interaction network for Crohn's disease in the Chinese population.

William K K Wu, Rui Sun, Tao Zuo, Yuanyuan Tian, Zhirong Zeng, Jeffery Ho, Justin C Y Wu, Francis K L Chan, Matthew T V Chan, Jun Yu and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Medicina (Kaunas, Lithuania) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

William K K WuState Key Laboratory of Digestive Diseases, Institute of Digestive Diseases and Department of Medicine & Therapeutics, LKS Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong.ORCID 0000-0002-6850-4454
Rui SunThe Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong.
Tao ZuoState Key Laboratory of Digestive Diseases, Institute of Digestive Diseases and Department of Medicine & Therapeutics, LKS Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong.
Yuanyuan TianDepartment of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong.
Zhirong ZengDepartment of Gastroenterology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Jeffery HoDepartment of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong.
Justin C Y WuState Key Laboratory of Digestive Diseases, Institute of Digestive Diseases and Department of Medicine & Therapeutics, LKS Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong.
Francis K L ChanState Key Laboratory of Digestive Diseases, Institute of Digestive Diseases and Department of Medicine & Therapeutics, LKS Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong.
Matthew T V ChanDepartment of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong.
Jun YuState Key Laboratory of Digestive Diseases, Institute of Digestive Diseases and Department of Medicine & Therapeutics, LKS Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong.
Joseph J Y SungState Key Laboratory of Digestive Diseases, Institute of Digestive Diseases and Department of Medicine & Therapeutics, LKS Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong.
Sunny H WongState Key Laboratory of Digestive Diseases, Institute of Digestive Diseases and Department of Medicine & Therapeutics, LKS Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong.
Maggie H WangThe Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong.
Siew C NgState Key Laboratory of Digestive Diseases, Institute of Digestive Diseases and Department of Medicine & Therapeutics, LKS Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong.ORCID 0000-0002-0061-4913
Chinese University of Hong Kong · HKSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The incidence of Crohn's disease is increasing in many Asian countries, but considerable differences in genetic susceptibility have been reported between Western and Asian populations. This study aimed to fine-map 23 previously reported Crohn's disease genes and identify their interactions in the Chinese population by Illumina-based targeted capture sequencing. Our results showed that the genetic polymorphism A>G at rs144982232 in MST1 showed the most significant association (P = 1.78 × 10

Indexed as

Genetic Predisposition to DiseaseGenome-Wide Association StudyAdultChinaCrohn DiseaseEpistasis, GeneticEthnicityFemaleGene Regulatory NetworksGenotypeHippo KinasesHumansIntracellular Signaling Peptides and ProteinsMiddle AgedPolymorphism, Single NucleotideProtein Serine-Threonine KinasesHippo KinasesIntracellular Signaling Peptides and ProteinsProtein Serine-Threonine KinasesSTK4 protein, humanCrohn's diseasefine mappinggene-gene interactionsMST1next-generation sequencing

Identifiers

PMID29441677
PMCPMC5867068
OpenAlexW2794089187

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.