Evidence map›Paper›PMID 29441471›Full record

Trial reportExperimental brain research2018

Transcranial direct current stimulation generates a transient increase of small-world in brain connectivity: an EEG graph theoretical analysis.

Fabrizio Vecchio, Riccardo Di Iorio, Francesca Miraglia, Giuseppe Granata, Roberto Romanello, Placido Bramanti, Paolo Maria Rossini

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Experimental brain research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05623072 (The Effect of tDCS on Emotion Recognition and EEG Oscillations in Healthy Adults), which is not on this map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05623072 nacompletednot on this mapstarted 2022, after this paper: background citation

The Effect of tDCS on Emotion Recognition and EEG Oscillations in Healthy Adults

TypeinterventionalSponsorIstanbul Medipol University HospitalRan2022 to 2023Enrolled56ConditionsEmotion RecognitionArmsActive tDCS, Sham tDCS
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 36 citations in OpenAlex.

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  13. tDCS effects on brain network properties during physiological aging.Pflugers Archiv : European journal of physiology · 2021
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  19. Tracking Changes in Brain Network Connectivity under Transcranial Current Stimulation.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Fabrizio VecchioBrain Connectivity Laboratory, IRCCS San Raffaele-Pisana, Via Val Cannuta, 247, 00166, Rome, Italy. fabrizio.vecchio@uniroma1.it.ORCID 0000-0002-6004-9522
Riccardo Di IorioDepartment Geriatrics, Neurosciences, Orthopedics, Policlinic A. Gemelli, Institute of Neurology, Catholic University, Rome, Italy.
Francesca MiragliaBrain Connectivity Laboratory, IRCCS San Raffaele-Pisana, Via Val Cannuta, 247, 00166, Rome, Italy.
Giuseppe GranataDepartment Geriatrics, Neurosciences, Orthopedics, Policlinic A. Gemelli, Institute of Neurology, Catholic University, Rome, Italy.
Roberto RomanelloDepartment Geriatrics, Neurosciences, Orthopedics, Policlinic A. Gemelli, Institute of Neurology, Catholic University, Rome, Italy.
Placido BramantiIRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy.
Paolo Maria RossiniBrain Connectivity Laboratory, IRCCS San Raffaele-Pisana, Via Val Cannuta, 247, 00166, Rome, Italy.
Agostino Gemelli University Polyclinic · ITCentro Neurolesi Bonino Pulejo · ITIRCCS Ospedale San Raffaele · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcranial direct current stimulation (tDCS) is a non-invasive technique able to modulate cortical excitability in a polarity-dependent way. At present, only few studies investigated the effects of tDCS on the modulation of functional connectivity between remote cortical areas. The aim of this study was to investigate-through graph theory analysis-how bipolar tDCS modulate cortical networks high-density EEG recordings were acquired before and after bipolar cathodal, anodal and sham tDCS involving the primary motor and pre-motor cortices of the dominant hemispherein 14 healthy subjects. Results showed that, after bipolar anodal tDCS stimulation, brain networks presented a less evident "small world" organization with a global tendency to be more random in its functional connections with respect to prestimulus condition in both hemispheres. Results suggest that tDCS globally modulates the cortical connectivity of the brain, modifying the underlying functional organization of the stimulated networks, which might be related to changes in synaptic efficiency of the motor network and related brain areas. This study demonstrated that graph analysis approach to EEG recordings is able to intercept changes in cortical functions mediated by bipolar anodal tDCS mainly involving the dominant M1 and related motor areas. Concluding, tDCS could be an useful technique to help understanding brain rhythms and their topographic functional organization and specificity.

Indexed as

Transcranial Direct Current StimulationAdultBrainBrain MappingElectroencephalographyFemaleHumansMaleMotor CortexNerve NetNeural PathwaysNeuronal PlasticityBrain networksEEGGraph analysisSmallworldtDCS

Identifiers

PMID29441471
OpenAlexW2788046649

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.