Evidence map›Paper›PMID 29441404›Full record

ArticlePflugers Archiv : European journal of physiology2018

PDGF-induced migration of synthetic vascular smooth muscle cells through c-Src-activated L-type Ca

Xiaoguang Guo, Toshihide Kashihara, Tsutomu Nakada, Toshifumi Aoyama, Mitsuhiko Yamada

Abstract read
PubMed Publisher
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Mechanisms of Vascular CaHandbook of experimental pharmacology · 2023
    Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Xiaoguang GuoDepartment of Molecular Pharmacology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.
Toshihide KashiharaDepartment of Molecular Pharmacology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.
Tsutomu NakadaDepartment of Molecular Pharmacology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.
Toshifumi AoyamaDepartment of Metabolic Regulation, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Matsumoto, Nagano, Japan.
Mitsuhiko YamadaDepartment of Molecular Pharmacology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan. myamada@shinshu-u.ac.jp.ORCID 0000-0002-7515-3824
Shinshu University · JP

Funding

Shinshu Public Utility Foundation for Promotion of Medical Sciences NAthe Ministry of Education, Culture, Sports, Science and Technology, Japan 16K08546
6 · The paper itself

Abstract

In atherosclerosis, vascular smooth muscle cells (VSMC) migrate from the media toward the intima of the arteries in response to cytokines, such as platelet-derived growth factor (PDGF). However, molecular mechanism underlying the PDGF-induced migration of VSMCs remains unclear. The migration of rat aorta-derived synthetic VSMCs, A7r5, in response to PDGF was potently inhibited by a Ca

Indexed as

Transendothelial and Transepithelial MigrationAnimalsAtherosclerosisCalcium Channels, L-TypeCells, CulturedHEK293 CellsHumansMaleMuscle, Smooth, VascularMyocytes, Smooth MusclePlatelet-Derived Growth FactorProtein DomainsRatsRats, Sprague-Dawleysrc-Family KinasesCalcium Channels, L-TypePlatelet-Derived Growth Factorsrc-Family KinasesCaV1.2 channelsc-SrcPlatelet-derived growth factorVascular smooth muscle cells

Identifiers

PMID29441404
OpenAlexW2791932027

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.