ArticleFrontiers in microbiology2018
Alanine Enhances Aminoglycosides-Induced ROS Production as Revealed by Proteomic Analysis.
Article in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 86 citations in OpenAlex.
- Article
- Resistance breakers: a novel approach to tackle biofilm associated infections and antimicrobial resistance.Frontiers in microbiology · 2026Review
- Proteomic Insights into Bacterial Responses to Antibiotics: A Narrative Review.International journal of molecular sciences · 2025Review
- The Cyclic Peptide Cyclo-zp80r ControlsFoods (Basel, Switzerland) · 2025Article
- Metabolic state-driven nutrient-based approach to combat bacterial antibiotic resistance.npj antimicrobials and resistance · 2025Review
- Antimicrobial Resistance and New Antimicrobial Agents, A Review of the Literature.Current medicinal chemistry · 2025Review
- Alanine supplementation enhancing cordycepin production in Cordyceps militaris via upregulation of Cns2 and Cns3 genes expression levels.Journal of food and drug analysis · 2024Article
- Article
- Exogenous NADH promotes the bactericidal effect of aminoglycoside antibiotics againstVirulence · 2024Article
- Identifying Potential Natural Antibiotics from Unani Formulas through Machine Learning Approaches.Antibiotics (Basel, Switzerland) · 2024Article
- Aminoglycoside uptake, stress, and potentiation in Gram-negative bacteria: new therapies with old molecules.Microbiology and molecular biology reviews : MMBR · 2023Review
- Fructose promotes ampicillin killing of antibiotic-resistantVirulence · 2023Article
- A novel ruthenium-silver based antimicrobial potentiates aminoglycoside activity againstmSphere · 2023Article
- Ampicillin-controlled glucose metabolism manipulates the transition from tolerance to resistance in bacteria.Science advances · 2023Article
- Riboflavin Targets the Cellular Metabolic and Ribosomal Pathways of Candida albicansMicrobiology spectrum · 2023Article
- Alanine-Dependent TCA Cycle Promotion Restores the Zhongshengmycin-Susceptibility inInternational journal of molecular sciences · 2023Article
- Comparative Metabolome Analyses of Ivermectin-Resistant and -Susceptible Strains ofAnimals : an open access journal from MDPI · 2023Article
- L-leucine increases the sensitivity of drug-resistantFrontiers in microbiology · 2023Article
- Glutamate-pantothenate pathway promotes antibiotic resistance ofFrontiers in microbiology · 2023Article
- A glucose-mediated antibiotic resistance metabolic flux from glycolysis, the pyruvate cycle, and glutamate metabolism to purine metabolism.Frontiers in microbiology · 2023Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolite-enabled killing of antibiotic-resistant pathogens by antibiotics is an attractive strategy to manage antibiotic resistance. Our previous study demonstrated that alanine or/and glucose increased the killing efficacy of kanamycin on antibiotic-resistant bacteria, whose action is through up-regulating TCA cycle, increasing proton motive force and enhancing antibiotic uptake. Despite the fact that alanine altered several metabolic pathways, other mechanisms could be potentially involved in alanine-mediated kanamycin killing of bacteria which remains to be explored. In the present study, we adopted proteomic approach to analyze the proteome changes induced by exogenous alanine. Our results revealed that the expression of three outer membrane proteins was altered and the deletion of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.