Evidence map›Paper›PMID 29440987›Full record

ArticleFrontiers in neuroscience2018

Metabolomics Based Identification of SIRT5 and Protein Kinase C Epsilon Regulated Pathways in Brain.

Kevin B Koronowski, Nathalie Khoury, Kahlilia C Morris-Blanco, Holly M Stradecki-Cohan, Timothy J Garrett, Miguel A Perez-Pinzon

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Article
  3. [Role of succinylation modification in central nervous system diseases].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Role of NADCellular and molecular neurobiology · 2023
    Review
  11. Article
  12. Review
  13. Roles of sirtuins in asthma.Respiratory research · 2022
    Review
  14. Article
  15. Progress on mitochondrial silence information regulator family in epilepsy.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2021
    Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kevin B KoronowskiCerebral Vascular Disease Research Laboratories, Miller School of Medicine, University of Miami, Miami, FL, United States.
Nathalie KhouryCerebral Vascular Disease Research Laboratories, Miller School of Medicine, University of Miami, Miami, FL, United States.
Kahlilia C Morris-BlancoCerebral Vascular Disease Research Laboratories, Miller School of Medicine, University of Miami, Miami, FL, United States.
Holly M Stradecki-CohanCerebral Vascular Disease Research Laboratories, Miller School of Medicine, University of Miami, Miami, FL, United States.
Timothy J GarrettSoutheast Center for Integrated Metabolomics, Clinical and Translational Science Institute, University of Florida, Gainesville, FL, United States.
Miguel A Perez-PinzonCerebral Vascular Disease Research Laboratories, Miller School of Medicine, University of Miami, Miami, FL, United States.
University of Miami · USUniversity of Florida · US

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
ISCHEMIC PRECONDITIONING: MECHANISMS OF NEUROPROTECTIONR01NS034773 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MIGUEL A PEREZ-PINZON · 2003 to 2026
$6.7M
MECHANISMS OF NEUROPROTECTION AGAINST CARDIAC ARRESTR01NS045676 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI PEREZ-PINZON, MIGUEL A · 2004 to 2024
$5.1M
Metabolic Master Regulators for Ischemic NeuroprotectionR01NS097658 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI PEREZ-PINZON, MIGUEL A · 2017 to 2021
$2.1M
ISCHEMIC PRECONDITIONING: MECHANISMS OF NEUROPROTECTIONRF1NS034773 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI PEREZ-PINZON, MIGUEL A · 2022 to 2022
$1.7M
ISCHEMIC PRECONDITIONING--MECHANISMS OF NEUROPROTECTIONR29NS034773 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI PEREZ-PINZON, MIGUEL A · 1997 to 2001
$267k
Neuroprotective mechanims of reseveratrol pre-conditioningF31NS089356 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI KORONOWSKI, KEVIN B · 2015 to 2017
$93k
NCATS NIH HHS UL1 TR001427NINDS NIH HHS F31 NS089356NINDS NIH HHS R01 NS034773NINDS NIH HHS R01 NS045676NINDS NIH HHS R01 NS097658NINDS NIH HHS R29 NS034773NINDS NIH HHS RF1 NS034773
6 · The paper itself

Abstract

The role of Sirtuins in brain function is emerging, yet little is known about SIRT5 in this domain. Our previous work demonstrates that protein kinase C epsilon (PKCε)-induced protection from focal ischemia is lost in SIRT5

Indexed as

brain metabolismcerebral ischemiaischemic preconditioningprotein kinase C epsilonSIRT5sirtuins

Identifiers

PMID29440987
PMCPMC5797631
OpenAlexW2791059728

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.