Evidence map›Paper›PMID 29440900›Full record

ArticleInternational journal of nanomedicine2018

Gestational exposure to titanium dioxide nanoparticles impairs the placentation through dysregulation of vascularization, proliferation and apoptosis in mice.

Lu Zhang, Xingxing Xie, Yigang Zhou, Dainan Yu, Yu Deng, Jiexiu Ouyang, Bei Yang, Dan Luo, Dalei Zhang, Haibin Kuang

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 93 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Hepatotoxicity of titanium dioxide nanoparticles.Journal of applied toxicology : JAT · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Nanoparticles at the maternal-fetal interface.Molecular and cellular endocrinology · 2023
    Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Teratological effects of titanium dioxide nanoparticles in mice embryo.Environmental science and pollution research international · 2022
    Article
  16. Review
  17. Article
  18. Article
  19. Fetotoxicity of Nanoparticles: Causes and Mechanisms.Nanomaterials (Basel, Switzerland) · 2021
    Review
  20. Vaginal Exposure toFrontiers in microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Lu Zhang *Department of Physiology, Basic Medical College, Nanchang University, Nanchang.
Xingxing Xie *Department of Physiology, Basic Medical College, Nanchang University, Nanchang.
Yigang Zhou *Department of Color Ultrasonic Room, No 96716 Hospital of PLA.
Dainan YuDepartment of Physiology, Basic Medical College, Nanchang University, Nanchang.
Yu DengDepartment of Physiology, Basic Medical College, Nanchang University, Nanchang.
Jiexiu OuyangJiangxi Provincial Key Laboratory of Reproductive Physiology and Pathology, Medical Experimental Teaching Center, Nanchang University, Nanchang, Jiangxi, People's Republic of China.
Bei YangDepartment of Physiology, Basic Medical College, Nanchang University, Nanchang.
Dan LuoDepartment of Physiology, Basic Medical College, Nanchang University, Nanchang.
Dalei ZhangDepartment of Physiology, Basic Medical College, Nanchang University, Nanchang.
Haibin KuangDepartment of Physiology, Basic Medical College, Nanchang University, Nanchang.
Nanchang University · CNUltrasonic Technologies (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTitanium dioxide nanoparticles (TiO PURPOSE: The objective of this study was to investigate the effects of maternal exposure of TiO

methodsMice were administered TiO

resultsNo treatment-related difference was observed in the numbers of implanted and resorbed embryos and weight of placenta between the groups. However, 1 mg/kg/day TiO

conclusionGestational exposure to TiO

Indexed as

AnimalsApoptosisbcl-2-Associated X ProteinCaspase 3Cell ProliferationFemaleGene Expression Regulation, DevelopmentalMaternal ExposureMetal NanoparticlesMiceNeovascularization, PathologicOrgan SizePlacentaPlacentationPregnancyTitaniumbcl-2-Associated X ProteinCaspase 3Titaniumtitanium dioxideapoptosisnanoparticlesplacentaproliferationtitanium dioxidevascularization

Identifiers

PMID29440900
PMCPMC5804269
OpenAlexW2790090409

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.