ArticleScientific reports2018
Highly variable contractile performance correlates with myocyte content in trabeculae from failing human hearts.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- βNaunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Myocardial composition and contractile function of right atrial trabeculae from type 2 diabetic and nondiabetic male patients.Physiological reports · 2025Article
- Human cardiac tissues produce lower contractile stress and exhibit slower cross-bridge cycling in type 2 diabetes.Cardiovascular diabetology · 2025Article
- Preparation of Human Atrial Trabeculae for Ex Vivo Analysis of Human Myocardial Function.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Recent advances in quantifying the mechanobiology of cardiac development via computational modeling.Current opinion in biomedical engineering · 2023Article
- Impaired calcium handling mechanisms in atrial trabeculae of diabetic patients.Physiological reports · 2023Article
- The interplay between cardiac dyads and mitochondria regulated the calcium handling in cardiomyocytes.Frontiers in physiology · 2022Review
- Diffuse myocardial fibrosis: mechanisms, diagnosis and therapeutic approaches.Nature reviews. Cardiology · 2021Review
- Effects of omecamtiv mecarbil on failing human ventricular trabeculae and interaction with (-)-noradrenaline.Pharmacology research & perspectives · 2021Article
- Targeting JP2: A New Treatment for Pulmonary Hypertension.Oxidative medicine and cellular longevity · 2021Review
- Human Atrial Fibrillation Is Not Associated With Remodeling of Ryanodine Receptor Clusters.Frontiers in cell and developmental biology · 2021Article
- Intact myocardial preparations reveal intrinsic transmural heterogeneity in cardiac mechanics.Journal of molecular and cellular cardiology · 2020Article
- Calcium Signaling in Cardiomyocyte Function.Cold Spring Harbor perspectives in biology · 2020Review
- Three-Dimensional and Chemical Mapping of Intracellular Signaling Nanodomains in Health and Disease with Enhanced Expansion Microscopy.ACS nano · 2019Article
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Authors and funding
6 authors.
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Abstract
Heart failure (HF) is defined by compromised contractile function and is associated with changes in excitation-contraction (EC) coupling and cardiomyocyte organisation. Tissue level changes often include fibrosis, while changes within cardiomyocytes often affect structures critical to EC coupling, including the ryanodine receptor (RyR), the associated protein junctophilin-2 (JPH2) and the transverse tubular system architecture. Using a novel approach, we aimed to directly correlate the influence of structural alterations with force development in ventricular trabeculae from failing human hearts. Trabeculae were excised from explanted human hearts in end-stage failure and immediately subjected to force measurements. Following functional experiments, each trabecula was fixed, sectioned and immuno-stained for structural investigations. Peak stress was highly variable between trabeculae from both within and between failing hearts and was strongly correlated with the cross-sectional area occupied by myocytes (MCSA), rather than total trabecula cross-sectional area. At the cellular level, myocytes exhibited extensive microtubule densification which was linked via JPH2 to time-to-peak stress. Trabeculae fractional MCSA variability was much higher than that in adjacent free wall samples. Together, these findings identify several structural parameters implicated in functional impairment in human HF and highlight the structural variability of ventricular trabeculae which should be considered when interpreting functional data.
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