Evidence map›Paper›PMID 29440721›Full record

ArticleScientific reports2018

Salt-bridge modulates differential calcium-mediated ligand binding to integrin α1- and α2-I domains.

Kyle L Brown, Surajit Banerjee, Andrew Feigley, Hanna Abe, Timothy S Blackwell, Ambra Pozzi, Billy G Hudson, Roy Zent

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. CaCells · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. The Vanderbilt O'Brien Kidney Center.American journal of physiology. Renal physiology · 2021
    Review
  8. Article
  9. Article
  10. Structural basis for anthrax toxin receptor 1 recognition by Seneca Valley Virus.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Kyle L BrownDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232-2372, USA. kyle.l.brown@vanderbilt.edu.ORCID 0000-0002-7671-1912
Surajit BanerjeeDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853, USA.
Andrew FeigleyLeadership Alliance, Vanderbilt University Medical Center, Nashville, TN, 37232-2372, USA.
Hanna AbeAspirnaut Summer research program, Vanderbilt University Medical Center, Nashville, TN, 37232-2372, USA.
Timothy S BlackwellDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232-2372, USA.
Ambra PozziDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232-2372, USA.
Billy G HudsonDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232-2372, USA.
Roy ZentDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232-2372, USA.
Vanderbilt University Medical Center · USVeterans Health Administration · USArgonne National Laboratory · USVanderbilt University · US

Funding

Mechanisms of Familial Pulmonary FibrosisP01HL092870 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SCHWARTZ, DAVID ALBERT · 2010 to 2020
$21.6M
Overall EvaluationP41GM103403 · NIGMS · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2012 to 2017
$14.3M
STUDIES ON THE STRUCTURE OF BASEMENT MEMBRANESR01DK018381 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Sergey Petrovich Budko, BILLY GERALD HUDSON · 1986 to 2026
$12.4M
The Laminin Receptors in Kidney FibrosisR01DK069921 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ROY ZENT · 2005 to 2026
$9.5M
Interdisciplinary Training Program in Lung ResearchT32HL094296 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ray Stokes Peebles · 2008 to 2026
$6.3M
Vanderbilt O'Brien Kidney Center - Core D - Clinical and Translational CoreP30DK114809 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WILSON, MATTHEW H · 2017 to 2021
$5.9M
Pixel Array Detector for X-ray CrystallographyS10RR029205 · NCRR · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2010 to 2010
$1.8M
Matrix receptors in chronic kidney diseaseR01DK119212 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BORZA, CORINA MARILENA, POZZI, AMBRA · 2018 to 2022
$1.7M
Undergraduate Research Internships in Pathobiology of Diabetic NephropathyR25DK096999 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BILLY GERALD HUDSON · 2012 to 2026
$1.6M
Integrin/TGF-beta Axis in Tubulointerstitial FibrosisR01DK095761 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI POZZI, AMBRA · 2013 to 2016
$1.4M
The ILK/PINCH/Parvin complex in renal tubulogenesisI01BX002196 · VA · VETERANS HEALTH ADMINISTRATION · PI ZENT, ROY · 2013 to 2025
–
Role of Collagen Binding Receptors in GlomerulosclerosisI01BX002025 · VA · VETERANS HEALTH ADMINISTRATION · PI AMBRA POZZI · 2013 to 2026
–
BLRD VA I01 BX002025BLRD VA I01 BX002196NCRR NIH HHS S10 RR029205NHLBI NIH HHS P01 HL092870NHLBI NIH HHS T32 HL094296NIDDK NIH HHS L40 DK069221NIDDK NIH HHS P30 DK114809NIDDK NIH HHS R01 DK018381NIDDK NIH HHS R01 DK069921NIDDK NIH HHS R01 DK095761NIDDK NIH HHS R01 DK119212NIDDK NIH HHS R25 DK096999NIGMS NIH HHS P41 GM103403
6 · The paper itself

Abstract

Integrins are transmembrane cell-extracellular matrix adhesion receptors that impact many cellular functions. A subgroup of integrins contain an inserted (I) domain within the α-subunits (αI) that mediate ligand recognition where function is contingent on binding a divalent cation at the metal ion dependent adhesion site (MIDAS). Ca

Indexed as

Amino Acid SequenceCalciumHydrogen BondingIntegrin alpha1Integrin alpha2LigandsModels, MolecularProtein BindingProtein DomainsThermodynamicsCalciumIntegrin alpha1Integrin alpha2Ligands

Identifiers

PMID29440721
PMCPMC5811549
OpenAlexW2807431270

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.