ArticleScientific reports2018
Age-related changes in the response of retinal structure, function and blood flow to pressure modification in rats.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Response of the Rat Eye to Acute and Chronic Optic Nerve Pressure Modifications.Investigative ophthalmology & visual science · 2026Article
- Effect of intracerebral infusion rate on optic nerve tissue pressure and diurnal intracranial pressure in rats.Fluids and barriers of the CNS · 2025Article
- Rat retinal function attenuation with IOP elevation is impacted by both blood pressure and intracranial pressure.Frontiers in physiology · 2025Article
- Aging, Cellular Senescence, and Glaucoma.Aging and disease · 2024Review
- Retinal electrophysiologic response to IOP elevation in living human eyes.Experimental eye research · 2023Article
- Relationship between edema and intracranial pressure following intracerebral hemorrhage in rat.Frontiers in stroke · 2023Review
- The Effect of Aging on Retinal Function and Retinal Ganglion Cell Morphology Following Intraocular Pressure Elevation.Frontiers in aging neuroscience · 2022Article
- In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography.Journal of visualized experiments : JoVE · 2020Article
- Modeling a potential SANS countermeasure by experimental manipulation of the translaminar pressure difference in mice.NPJ microgravity · 2020Article
- In vivo optic nerve head mechanical response to intraocular and cerebrospinal fluid pressure: imaging protocol and quantification method.Scientific reports · 2018Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Age-related changes to the balance between the pressure inside the eye (intraocular pressure, IOP) and the pressure inside the brain (intracranial pressure, ICP) can modify the risk of glaucoma. In this study, we consider whether the optic nerve in older rat eyes is more susceptible to acute IOP and ICP modification. We systematically manipulate both ICP and IOP and quantify their effects on ganglion cell function (electroretinography, ERG), optic nerve structure (optical coherence tomography, OCT) and retinal blood flow (Doppler OCT). We show that ganglion cell function in older eyes was more susceptible to a higher optic nerve pressure difference (ONPD = IOP - ICP). This age-related susceptibility could not be explained by poorer blood flow with elevated ONPD. Rather, as ONPD increased the retinal nerve fibre layer showed greater compression, and the retinal surface showed less deformation in older eyes. Our data suggest that age-related changes to connective tissues in and around the rat optic nerve make it less flexible, which may result in greater strain on ganglion cell axons. This may account for greater functional susceptibility to higher optic nerve pressure differences in older rat eyes. Further studies in a species with a well-developed lamina cribrosa are needed to determine the clinical importance of these observations.
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