Evidence map›Paper›PMID 29440698›Full record

ArticleScientific reports2018

Gold Nanoparticles-enabled Efficient Dual Delivery of Anticancer Therapeutics to HeLa Cells.

Muhammad U Farooq, Valentyn Novosad, Elena A Rozhkova, Hussain Wali, Asghar Ali, Ahmed A Fateh, Purnima B Neogi, Arup Neogi, Zhiming Wang

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 225 citations in OpenAlex.

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  13. Spectrophotometric Analysis and Optimization of 2D Gold Nanosheet Formation.The journal of physical chemistry. C, Nanomaterials and interfaces · 2023
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 5 countries.

Muhammad U FarooqInstitute of Fundamental and Frontier Science, University of Electronic Science and Technology of China, 610054, Chengdu, China. ufbajwa@yahoo.com.
Valentyn NovosadMaterials Science Division, Argonne National Laboratory, Argonne, IL, 60439, USA.ORCID 0000-0003-2127-2374
Elena A RozhkovaNanoscience and Technology Division, Center for Nanoscale Materials, Argonne National Laboratory, Argonne, IL, 60439, USA.
Hussain WaliInstitute of Fundamental and Frontier Science, University of Electronic Science and Technology of China, 610054, Chengdu, China.
Asghar AliDepartment of Physics, International Islamic University Islamabad, Islamabad, 44000, Pakistan.
Ahmed A FatehSchool of Life Science and Technology, University of Electronic Science and Technology of China, 610054, Chengdu, China.
Purnima B NeogiDepartment of Biological Science, University of North Texas, Denton, TX, 76203, USA.
Arup NeogiDepartment of Physics, University of North Texas, Denton, TX, 76203, USA.
Zhiming WangInstitute of Fundamental and Frontier Science, University of Electronic Science and Technology of China, 610054, Chengdu, China.
University of Electronic Science and Technology of China · CNUniversity of North Texas · USArgonne National Laboratory · USInternational Islamic University, Islamabad · PKNational University of Science and Technology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colloidal gold nanoparticles (AuNPs) are of interest as non-toxic carriers for drug delivery owing to their advanced properties, such as extensive surface-to-volume ratio and possibilities for tailoring their charge, hydrophilicity and functionality through surface chemistries. To date, various biocompatible polymers have been used for surface decoration of AuNPs to enhance their stability, payloads capacity and cellular uptake. This study describes a facile one-step method to synthesize stable AuNPs loaded with combination of two anticancer therapeutics, -bleomycin and doxorubicin. Anticancer activities, cytotoxicity, uptake and intracellular localization of the AuNPs were demonstrated in HeLa cells. We show that the therapeutic efficacy of the nanohybrid drug was strongly enhanced by the active targeting by the nanoscale delivery system to HeLa cells with a significant decrease of the half-maximal effective drug concentration, through blockage of HeLa cancer cell cycle. These results provide rationale for further progress of AuNPs-assisted combination chemotherapy using two drugs at optimized effective concentrations which act via different mechanisms thus decreasing possibilities of development of the cancer drug resistance, reduction of systemic drug toxicity and improvement of outcomes of chemotherapy.

Indexed as

Antineoplastic AgentsDoxorubicinDrug CarriersGoldHeLa CellsHumansMetal NanoparticlesParticle SizePolyethylene GlycolsAntineoplastic AgentsDoxorubicinDrug CarriersGoldPolyethylene Glycols

Identifiers

PMID29440698
PMCPMC5811504
OpenAlexW2792927819

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.