ArticleScientific reports2018
Combination of nutritional polyphenols supplementation with exercise training counteracts insulin resistance and improves endurance in high-fat diet-induced obese rats.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Bioactives and exercise synergize to modulate AMPK and inflammation.Frontiers in immunology · 2025Pooled it
- The Effects of Polyphenol Supplementation in Addition to Calorie Restricted Diets and/or Physical Activity on Body Composition Parameters: A Systematic Review of Randomized Trials.Frontiers in nutrition · 2020Pooled it
- Effect of Calafate (Journal of nutrition and metabolism · 2026Article
- Applications of food science innovations in sports nutrition: from laboratory research to endurance sports practice.Frontiers in nutrition · 2026Review
- Integrative approaches to healthy aging in postmenopausal women: the synergistic benefits of exercise combined with functional foods and dietary supplements.Frontiers in endocrinology · 2026Review
- Application of Exercise/Training Models to Evaluate Food Functionality with Special Focus on Preventing Inflammation and Oxidative Stress and Enhancing Exercise Performance.Foods (Basel, Switzerland) · 2025Review
- Effects of defined voluntary running distances coupled with high-fat diet consumption on the skeletal muscle transcriptome of male mice.Physiological reports · 2025Article
- Synergistic potential of natural products and exercise: unveiling molecular mechanisms and innovative therapeutic approaches for liver diseases.Frontiers in nutrition · 2025Review
- Synergistic effects of polyphenols and exercise on obesity: targeting metabolism, muscle function, and adipose tissue remodeling.Frontiers in nutrition · 2025Review
- Exercise ameliorates muscular excessive mitochondrial fission, insulin resistance and inflammation in diabetic rats via irisin/AMPK activation.Scientific reports · 2024Article
- Syrah Grape Polyphenol Extracts Protect Human Skeletal Muscle Cells from Oxidative and Metabolic Stress Induced by Excess of Palmitic Acid: Effect of Skin/Seed Ripening Stage.Antioxidants (Basel, Switzerland) · 2024Article
- Effects Of Exercise Training And Chlorogenic Acid Supplementation On Hepatic Lipid Metabolism In Prediabetes Mice.Diabetes & metabolism journal · 2023Article
- Article
- Plant-Based Nutrition: Exploring Health Benefits for Atherosclerosis, Chronic Diseases, and Metabolic Syndrome-A Comprehensive Review.Nutrients · 2023Review
- Effect of Isoquercitrin on Free Fatty Acid-Induced Lipid Accumulation in HepG2 Cells.Molecules (Basel, Switzerland) · 2023Article
- Grape Polyphenols in the Treatment of Human Skeletal Muscle Damage Due to Inflammation and Oxidative Stress during Obesity and Aging: Early Outcomes and Promises.Molecules (Basel, Switzerland) · 2022Review
- Blueberry juice augments exercise-induced neuroprotection in a Parkinson's disease model through modulation of GDNF levels.IBRO neuroscience reports · 2022Article
- High-fat diet-induced memory impairment and anxiety-like behavior in rats attenuated by peel extract ofMetabolism open · 2021Article
- Grape Polyphenols Ameliorate Muscle Decline Reducing Oxidative Stress and Oxidative Damage in Aged Rats.Nutrients · 2020Article
- Diet-induced DNA methylation within the hypothalamic arcuate nucleus and dysregulated leptin and insulin signaling in the pathophysiology of obesity.Food science & nutrition · 2019Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Separately, polyphenols and exercise are known to prevent insulin resistance (IR) but their combined curative effects on established obesity and IR require further investigation. Therefore, we compared the metabolic effects of a combination of exercise and grape polyphenols supplementation in obese IR rats with high-fat diet (EXOPP) to the effect of high-fat diet alone (HF) or with a nutritional supplementation of grape polyphenols (PP) or with endurance exercise (EXO) during 8 wks. We observed an improvement of systemic and skeletal muscle insulin sensitivity in EXO and EXOPP rats. EXOPP rats compared to HF rats presented a lower insulinemia and HOMA-IR with higher liver and muscle glycogen contents. Interestingly, EXOPP rats had a 68% enhanced endurance capacity compared to EXO rats with also a higher activation of AMPK compared to sedentary and EXO rats with increased lipid oxidation. Together, our results suggest that grape polyphenols supplementation combined with exercise has a synergistic effect by increasing muscle lipid oxidation and sparing glycogen utilization which thus enhances endurance capacity. Our data highlight that in cases of established obesity and IR, the combination of nutritional grape polyphenols supplementation and exercise heighten and intensify their individual metabolic effects.
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