ArticleScientific reports2018
Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases - a comparative study of leishmaniasis and sporotrichosis.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- [Evaluation of the immunological profile of older adults according to Brazilian regions: results of ELSI-Brazil].Cadernos de saude publica · 2026Article
- Immune genes CD247 STAT1 and LCK mediate host-pathogen interactions in sporotrichosis.Scientific reports · 2025Article
- Ear Sporotrichosis Mimicking Cutaneous Leishmaniasis.The American journal of tropical medicine and hygiene · 2025Article
- An Immune-Based Therapeutical Approach in an Elderly Patient With Fixed Cutaneous Sporotrichosis.Cureus · 2024Article
- cFLIPCellular & molecular immunology · 2023Article
- The Role of Macrophages in the Host's Defense againstPathogens (Basel, Switzerland) · 2021Review
- Murine Susceptibility toFrontiers in cellular and infection microbiology · 2021Article
- A Cytokine Network Balance Influences the Fate ofFrontiers in immunology · 2021Article
- NOMolecules (Basel, Switzerland) · 2019Article
- In-situ immune profile of polymorphic vs. macular Indian Post Kala-azar dermal leishmaniasis.International journal for parasitology. Drugs and drug resistance · 2019Article
- Sporotrichosis In Immunocompromised Hosts.Journal of fungi (Basel, Switzerland) · 2019Review
- Immunopathogenesis of Human Sporotrichosis: What We Already Know.Journal of fungi (Basel, Switzerland) · 2018Review
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11 authors at 2 institutions in 1 country.
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Abstract
The clinical presentations of skin diseases produced by different pathogens, as American tegumentary leishmaniasis (ATL) and sporotrichosis can be similar and possibly influenced by the skin immune system (SIS). The aim of the study was to understand the underlying mechanisms of skin inflammation produced by different pathogens. We used immunohistochemistry to analyze 96 patients: a- localized cutaneous leishmaniasis (LCL-ATL); b- sporotrichoid cutaneous leishmaniasis (SCL-ATL); c-lymphocutaneous (LC-SP); d- fixed (F-SP) sporotrichosis. LCL-ATL and SCL-ATL had a significantly higher percentage of CD8, FasL and NOS2 than sporotrichosis. In contrast, LC-SP had a substantially higher percentage of CD4, BCl2 and neutrophils than ATL lesions. These results indicated some differences in the profile of the in situ immune response suggesting that SIS is a complex, adaptable system capable of different responses to intracellular or extracellular pathogens. However, regardless of the etiological agents, the inflammatory reaction and clinical manifestations can be similar. SCL-ATL and LC-SP presented similarities in both clinical presentation and in situ inflammatory profile (CD3, CD22, neutrophils, macrophages). The clinical presentation of ATL and sporotrichosis could be explained by a combination of factors both of the host SIS and the etiological agent. The unbalanced host parasite relationship could result in atypical manifestations of skin disease.
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